Description

4-Fluorobenzophenone (CAS No. 345-83-5) is a high-purity fluorinated aromatic ketone with the molecular formula C₁₃H₉FO. This compound, also known by its IUPAC name (4-fluorophenyl)-phenylmethanone, is a versatile building block in organic synthesis and pharmaceutical research. Its unique structure, featuring a fluorine-substituted benzene ring conjugated with a benzophenone core, makes it valuable for UV absorption studies, photoinitiator applications, and as an intermediate in agrochemical and medicinal chemistry. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied as a crystalline solid with excellent shelf stability. Proper storage recommendations include protection from light and moisture at 2-8°C. Available in research quantities from grams to kilograms, this compound is ideal for method development, reference standards, and specialty chemical synthesis.

Properties

• CAS Number: 345-83-5
• Complexity: 213
• IUPAC Name: (4-fluorophenyl)-phenyl-methanone
• InChI: InChI=1S/C13H9FO/c14-12-8-6-11(7-9-12)13(15)10-4-2-1-3-5-10/h1-9H
• InChI Key: OGTSHGYHILFRHD-UHFFFAOYSA-N
• Exact Mass: 200.063743068
• Molecular Formula: C13H9FO
• Molecular Weight: 200.21
• SMILES: C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)F
• Topological: 17.1
• Monoisotopic Mass: 200.063743068
• Physical Description: Light beige crystalline powder;
• Synonyms: 4-Fluorobenzophenone, 345-83-5, EINECS 206-463-7, NSC 88321, DTXSID00188059, DTXCID80110550, 206-463-7, (4-Fluorophenyl)(phenyl)methanone, p-Fluorobenzophenone, (4-fluorophenyl)-phenylmethanone, Methanone, (4-fluorophenyl)phenyl-, 4-fluorophenyl phenyl ketone, MFCD00000352, JKA6JRZ9CD, NSC-88321, p-Fluorbenzophenon, UNII-JKA6JRZ9CD, Benzophenone, 4-fluoro-, Maybridge4_003548, p-Fluorophenyl phenyl ketone, 4-Fluorobenzophenone, 97%, NCIOpen2_001224, SCHEMBL251921, (4-Fluorophenyl)phenylmethanone, SCHEMBL3035196, SCHEMBL7525114, SCHEMBL8778426, SCHEMBL21050028, HMS1531B06, BCP26357, NSC88321, (4-Fluorophenyl)(phenyl)methanone #, AC9763, SBB057218, AKOS000118864, CCG-245108, FF12143, AS-10881, SY048330, DB-069036, CS-0130360, F0161, NS00041419, ST50758868, EN300-19553, BRD-K22255991-001-01-8, Q63398308, InChI=1/C13H9FO/c14-12-8-6-11(7-9-12)13(15)10-4-2-1-3-5-10/h1-9

Application

4-Fluorobenzophenone serves as a key intermediate in the synthesis of fluorinated liquid crystals for display technologies. It demonstrates utility as a photoinitiator in UV-curable coatings and inks due to its efficient light absorption properties. Researchers employ this compound as a model substrate for studying fluorine substitution effects on aromatic ketone reactivity. In pharmaceutical contexts, it functions as a precursor for antipsychotic and antidepressant drug candidates. The fluorinated benzophenone scaffold also finds use in materials science for developing advanced polymers with enhanced thermal stability.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.