Description

1-(Chloromethyl)-2-fluorobenzene (CAS No. 345-35-7) is a high-purity aromatic compound with the molecular formula C₇H₆ClF, widely utilized in organic synthesis and pharmaceutical research. This halogenated derivative of benzene features a reactive chloromethyl group adjacent to a fluorine substituent, making it a versatile intermediate for nucleophilic substitution reactions, cross-coupling, and functional group transformations. Available in >98% purity (GC), it is supplied in rigorously controlled conditions to ensure stability and consistency for sensitive applications. Ideal for synthesizing fluorinated analogs of bioactive molecules, ligands, or agrochemicals. Packaged in amber glass vials or sealed drums under inert gas to prevent degradation. MSDS and analytical certificates (CoA, NMR, HPLC) provided.

Properties

• CAS Number: 345-35-7
• Complexity: 85
• IUPAC Name: 1-(chloromethyl)-2-fluoro-benzene
• InChI: InChI=1S/C7H6ClF/c8-5-6-3-1-2-4-7(6)9/h1-4H,5H2
• InChI Key: MOBRMRJUKNQBMY-UHFFFAOYSA-N
• Exact Mass: 144.0142060
• Molecular Formula: C7H6ClF
• Molecular Weight: 144.57
• SMILES: C1=CC=C(C(=C1)CCl)F
• Monoisotopic Mass: 144.0142060
• Synonyms: 2-Fluorobenzyl chloride, 345-35-7, O-FLUOROBENZYL CHLORIDE, alpha-Chloro-o-fluorotoluene, Benzene, 1-(chloromethyl)-2-fluoro-, Toluene, alpha-chloro-o-fluoro-, EINECS 206-460-0, NSC 88295, DTXSID9059838, DTXCID2038863, 1-(Chloromethyl)-2-fluorobenzene, 1-Chloromethyl-2-fluoro-benzene, alpha-Chloro-2-fluorotoluene, 2-fluorobenzylchloride, 2-flourobenzyl chloride, MFCD00000892, o-fluorobenzylchloride, 2-fluoro-benzyl chloride, NCIOpen2_001365, 2-fluorophenylmethyl chloride, SCHEMBL69225, .alpha.-Chloro-o-fluorotoluene, 2-Fluorobenzyl chloride, 98%, SCHEMBL3959834, .alpha.-Chloro-2-fluorotoluene, SCHEMBL10976831, SCHEMBL21194024, SCHEMBL27453494, SCHEMBL28722118, MOBRMRJUKNQBMY-UHFFFAOYSA-, NSC88295, Toluene, .alpha.-chloro-o-fluoro-, NSC-88295, SBB040603, STL183090, AKOS000119256, AC-10797, DB-023913, F0211, NS00041566, ST50214000, EN300-18207, F2190-0268, InChI=1/C7H6ClF/c8-5-6-3-1-2-4-7(6)9/h1-4H,5H2

Application

1-(Chloromethyl)-2-fluorobenzene serves as a key building block in pharmaceutical intermediates, particularly for introducing fluorobenzyl motifs into drug candidates. It is employed in Suzuki-Miyaura couplings to create biaryl structures and in nucleophilic displacement reactions for heterocycle synthesis. Researchers also use it to develop fluorinated liquid crystals or agrochemicals due to its balanced reactivity and stability.

Safety and Hazards

GHS Hazard Statements

• H226 (98.7%): Flammable liquid and vapor [Warning Flammable liquids]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (67.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H400 (68.4%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
• H410 (68.4%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P264, P264+P265, P273, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P363, P370+P378, P391, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (98.7%)
• Skin Corr. 1B (100%)
• Eye Dam. 1 (67.7%)
• Aquatic Acute 1 (68.4%)
• Aquatic Chronic 1 (68.4%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.