Description

2-Amino-6-(trifluoromethyl)pyridine (CAS No. 34486-24-3) is a high-purity, specialty chemical compound with the molecular formula C₆H₅F₃N₂. This trifluoromethyl-substituted pyridine derivative is a versatile building block in pharmaceutical, agrochemical, and materials science research. Its unique structure, featuring an electron-withdrawing trifluoromethyl group and an amino functionality, makes it an invaluable intermediate for the synthesis of heterocyclic compounds, ligands, and active pharmaceutical ingredients (APIs).

Our product is rigorously tested for purity (≥97%) and consistency, ensuring optimal performance in synthetic applications. It is supplied as a crystalline solid with excellent shelf stability under recommended storage conditions (2-8°C, dry, inert atmosphere). Suitable for use in nucleophilic substitution reactions, metal-catalyzed cross-couplings, and as a precursor for functionalized pyridine derivatives.

Key Features:
– High chemical purity (≥97%)
– Batch-specific Certificate of Analysis
– Compatible with air-sensitive reactions
– Suitable for medicinal chemistry and material science applications

Properties

• CAS Number: 34486-24-3
• Complexity: 134
• IUPAC Name: 6-(trifluoromethyl)pyridin-2-amine
• InChI: InChI=1S/C6H5F3N2/c7-6(8,9)4-2-1-3-5(10)11-4/h1-3H,(H2,10,11)
• InChI Key: NFYYDQMFURPHCC-UHFFFAOYSA-N
• Exact Mass: 162.04048265
• Molecular Formula: C6H5F3N2
• Molecular Weight: 162.11
• SMILES: C1=CC(=NC(=C1)N)C(F)(F)F
• Topological: 38.9
• Monoisotopic Mass: 162.04048265
• Synonyms: 2-Amino-6-(trifluoromethyl)pyridine, 34486-24-3, DTXSID00356271, DTXCID10307330, 636-458-9, 6-(trifluoromethyl)pyridin-2-amine, 6-(trifluoromethyl)-2-pyridinylamine, MFCD03093868, EN300-61496, 2-Pyridinamine, 6-(trifluoromethyl)-, 6-(trifluoromethyl)-2-pyridylamine, 6-(trifluoromethyl)-2-pyridinamine, AQ-776/42801241, SCHEMBL181081, SCHEMBL21855912, 6-trifluoromethylpyridin-2-amine, PBPDHPGJRZUHJW-UHFFFAOYSA-N, 6-trifluoromethyl-pyridin-2ylamine, BDBM626191, 2-amino-6-trifluoromethyl-pyridine, 6-Trifluoromethyl-pyridin-2-ylamine, BBL102644, SBB028348, STL556447, AKOS005063709, AB13269, AC-2642, CS-W002995, DS-1625, FS-1212, SY002370, 2-Amino-6-(trifluoromethyl)pyridine, 97%, DB-005959, A2435, ST50408447, Z858035348

2-Amino-6-(trifluoromethyl)pyridine serves as a key intermediate in the synthesis of biologically active molecules, particularly in drug discovery for antiviral and anticancer agents. Its trifluoromethyl group enhances metabolic stability in pharmaceutical compounds. In materials science, it acts as a precursor for liquid crystals and OLED materials. The compound is also utilized in catalytic systems as a ligand for transition metals.

Safety and Hazards

GHS Hazard Statements

• H300 (83.7%): Fatal if swallowed [Danger Acute toxicity, oral]
• H301 (16.3%): Toxic if swallowed [Danger Acute toxicity, oral]
• H312 (12.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (83.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P272, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 2 (83.7%)
• Acute Tox. 3 (16.3%)
• Acute Tox. 4 (12.2%)
• Skin Irrit. 2 (100%)
• Skin Sens. 1 (83.7%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.