Description

2,6-Dichloro-4-fluoroaniline (CAS No. 344-19-4) is a high-purity halogenated aniline derivative with the molecular formula C₆H₄Cl₂FN. This fine chemical is widely utilized in pharmaceutical and agrochemical research as a key intermediate for the synthesis of advanced active ingredients. The compound features a benzene ring substituted with two chlorine atoms at the 2- and 6-positions, a fluorine atom at the 4-position, and an amino group, making it a versatile building block for heterocyclic compounds. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a crystalline solid with excellent batch-to-batch consistency. Suitable for use in Suzuki couplings, Buchwald-Hartwig aminations, and other palladium-catalyzed reactions. Packaged under inert gas to prevent oxidation and moisture absorption.

Properties

• CAS Number: 344-19-4
• Complexity: 110
• IUPAC Name: 2,6-dichloro-4-fluoro-aniline
• InChI: InChI=1S/C6H4Cl2FN/c7-4-1-3(9)2-5(8)6(4)10/h1-2H,10H2
• InChI Key: YAUYKCFMKMZTEX-UHFFFAOYSA-N
• Exact Mass: 178.9704827
• Molecular Formula: C6H4Cl2FN
• Molecular Weight: 180.00
• SMILES: C1=C(C=C(C(=C1Cl)N)Cl)F
• Topological: 26
• Monoisotopic Mass: 178.9704827
• Synonyms: 2,6-Dichloro-4-fluoroaniline, 344-19-4, 2,6-Dichloro-4-fluorobenzenamine, Benzenamine, 2,6-dichloro-4-fluoro-, QE7C2958V6, Aniline, 2,6-dichloro-4-fluoro-, (2,6-Dichloro-4-fluorophenyl)amine, DTXSID20378834, DTXCID20329861, 608-989-6, 2,6-dichloro-4-fluoro-aniline, 2,6-dichloro-4-fluorophenylamine, MFCD00142845, 2′,6′-dichloro-4′-fluoroaniline, 2,6,-Dichloro-4-fluoroaniline, UNII-QE7C2958V6, SCHEMBL1951099, SCHEMBL10801278, 2,6 Dichloro-4-fluorophenylamine, SBB051720, AKOS006230606, CS-W017244, AC-28632, DS-18170, FD105016, SY049506, DB-020162, D3625, ST50407532, EN300-109509, Z1201619297

Application

2,6-Dichloro-4-fluoroaniline serves as a critical precursor in the synthesis of fluorinated pharmaceuticals, particularly herbicides and fungicides. It is employed in the development of advanced crop protection agents due to its ability to modify bioavailability and metabolic stability. Researchers utilize this compound to create novel heterocyclic scaffolds for drug discovery programs targeting CNS and antimicrobial therapies. The fluorine substitution enhances binding affinity in many biologically active molecules.

Safety and Hazards

GHS Hazard Statements

• H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
• H311 (100%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H330 (12.5%): Fatal if inhaled [Danger Acute toxicity, inhalation]
• H331 (37.5%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H335 (12.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (62.5%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
• H400 (62.5%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
• H410 (62.5%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P320, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (100%)
• Acute Tox. 3 (100%)
• Skin Irrit. 2 (75%)
• Eye Irrit. 2 (75%)
• Acute Tox. 2 (12.5%)
• Acute Tox. 3 (37.5%)
• STOT SE 3 (12.5%)
• STOT RE 2 (62.5%)
• Aquatic Acute 1 (62.5%)
• Aquatic Chronic 1 (62.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.