Description

2-Bromo-3-methylpyridine (CAS No. 3430-17-9) is a high-purity heterocyclic organic compound with the molecular formula C₆H₆BrN. This versatile brominated pyridine derivative is an essential intermediate in pharmaceutical, agrochemical, and material science research. Its molecular weight of 172.02 g/mol and distinct reactivity make it ideal for cross-coupling reactions, such as Suzuki-Miyaura and Negishi couplings, as well as nucleophilic substitutions.

Available in >98% purity (GC), this compound is supplied as a clear to pale yellow liquid with a characteristic pyridine odor. It is packaged under inert gas to ensure stability and shipped with detailed analytical certificates (including ¹H NMR, ¹³C NMR, and GC-MS data). Store at 2-8°C in tightly sealed containers away from light and moisture.

Key applications include: building block for kinase inhibitors, ligand synthesis in catalysis, and functional material development. Compatible with anhydrous reactions and organometallic chemistry.

Properties

• CAS Number: 3430-17-9
• Complexity: 74.9
• IUPAC Name: 2-bromo-3-methyl-pyridine
• InChI: InChI=1S/C6H6BrN/c1-5-3-2-4-8-6(5)7/h2-4H,1H3
• InChI Key: PZSISEFPCYMBDL-UHFFFAOYSA-N
• Exact Mass: 170.96836
• Molecular Formula: C6H6BrN
• Molecular Weight: 172.02
• SMILES: CC1=C(N=CC=C1)Br
• Topological: 12.9
• Monoisotopic Mass: 170.96836
• Synonyms: 2-bromo-3-methylpyridine, 3430-17-9, PZSISEFPCYMBDL-UHFFFAOYSA-, DTXSID80277793, DTXCID70228951, 629-415-0, inchi=1/c6h6brn/c1-5-3-2-4-8-6(5)7/h2-4h,1h3, 2-Bromo-3-picoline, MFCD00239380, 2-bromo-3-methylpyridin, 2-Bromo-3-methyl-pyridine, 3-methyl-2-bromopyridine, 2-bromo-3-methyl pyridine, Pyridine, 2-bromo-3-methyl-, NSC4244, 2-bromo-3-mehtylpyridine, SCHEMBL9573, 2-Bromo-3-methylpyridine (2-Bromo-3-picoline), SCHEMBL229786, SCHEMBL1310638, SCHEMBL14127054, 2-Bromo-3-methylpyridine, 95%, PZSISEFPCYMBDL-UHFFFAOYSA-N, BCP23299, NSC 4244, NSC-4244, STR06862, SBB054403, AKOS005255176, AB05448, AC-5973, CS-W007712, FB31195, HY-W007712, PS-5114, SY008917, A6035, B1894, ST50827464, EN300-68298, AC-907/30003020, doi:10.14272/PZSISEFPCYMBDL-UHFFFAOYSA-N.2, Z968908232

Application

2-Bromo-3-methylpyridine serves as a critical precursor in medicinal chemistry for developing tyrosine kinase inhibitors and other bioactive molecules. Its bromine moiety enables efficient palladium-catalyzed cross-coupling reactions to construct complex heterocyclic systems. Researchers also utilize this compound as a directing group in C-H activation chemistry and as a scaffold for N-heterocyclic carbene ligands in transition metal catalysis.

Safety and Hazards

GHS Hazard Statements

• H302 (12.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (12.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (12.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (87.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (12.5%)
• Acute Tox. 4 (12.5%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (12.5%)
• STOT SE 3 (87.5%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.