Description

7-Bromo-2,3-dichloropyrido[2,3-b]pyrazine (CAS No. 341939-31-9) is a high-purity heterocyclic compound with the molecular formula C₇H₂BrCl₂N₃. This specialized chemical features a pyrido[2,3-b]pyrazine core structure substituted with bromo and dichloro functional groups, offering unique reactivity for advanced synthetic applications. With a molecular weight of 281.92 g/mol, this compound is supplied as a crystalline solid with >95% purity (HPLC). Ideal for pharmaceutical research, materials science, and agrochemical development, this building block is particularly valuable for nucleophilic aromatic substitution reactions and metal-catalyzed cross-coupling chemistry. Proper storage at 2-8°C under inert atmosphere is recommended to maintain stability.

Properties

• CAS Number: 341939-31-9
• Complexity: 195
• IUPAC Name: 7-bromo-2,3-dichloro-pyrido[2,3-b]pyrazine
• InChI: InChI=1S/C7H2BrCl2N3/c8-3-1-4-7(11-2-3)13-6(10)5(9)12-4/h1-2H
• InChI Key: XOXWPDIAPAYCKK-UHFFFAOYSA-N
• Exact Mass: 276.88092
• Molecular Formula: C7H2BrCl2N3
• Molecular Weight: 278.92
• SMILES: C1=C(C=NC2=C1N=C(C(=N2)Cl)Cl)Br
• Topological: 38.7
• Monoisotopic Mass: 276.88092
• Synonyms: 7-bromo-2,3-dichloropyrido[2,3-b]pyrazine, 341939-31-9, 7-Bromo-2,3-dichloropyrido(2,3-b)pyrazine, 890-033-4, Pyrido[2,3-b]pyrazine, 7-bromo-2,3-dichloro-, MFCD00461036, 7-bromo-2,3-dichloro-pyrido[2,3-b]pyrazine, SCHEMBL4681658, TQR0779, XOXWPDIAPAYCKK-UHFFFAOYSA-N, AKOS022421482, SB74260, AS-65099, DB-318266, CS-0060743, W17617, EN300-4256035

Application

7-Bromo-2,3-dichloropyrido[2,3-b]pyrazine serves as a key intermediate in the synthesis of complex nitrogen-containing heterocycles for drug discovery programs. Researchers utilize this compound in palladium-catalyzed coupling reactions to construct novel kinase inhibitor scaffolds. The electron-deficient pyrazine ring system makes it particularly useful for developing materials with unique optoelectronic properties. In medicinal chemistry, this building block has shown potential for creating targeted therapies due to its ability to participate in sequential substitution reactions.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)

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