Description

2-Furoic acid hydrazide (CAS No. 3326-71-4) is a high-purity heterocyclic organic compound with the molecular formula C₅H₆N₂O₂, widely utilized in pharmaceutical and chemical research. This compound, also known as furan-2-carbohydrazide, features a furan ring core functionalized with a carbohydrazide group, making it a versatile intermediate for synthesizing biologically active molecules. With a molecular weight of 126.11 g/mol, it is supplied as a white to off-white crystalline powder with ≥98% purity (HPLC), ensuring consistency for sensitive applications. Ideal for researchers developing antimicrobial, antifungal, or anticancer agents, 2-Furoic acid hydrazide is rigorously tested for impurities (≤0.5% by GC) and stored under controlled conditions to guarantee stability. Available in scalable quantities from milligrams to kilograms, it is packaged in amber glass vials or polyethylene containers with optional argon padding for oxidation-sensitive workflows.

Properties

• CAS Number: 3326-71-4
• Complexity: 116
• IUPAC Name: furan-2-carbohydrazide
• InChI: InChI=1S/C5H6N2O2/c6-7-5(8)4-2-1-3-9-4/h1-3H,6H2,(H,7,8)
• InChI Key: SKTSVWWOAIAIKI-UHFFFAOYSA-N
• Exact Mass: 126.042927438
• Molecular Formula: C5H6N2O2
• Molecular Weight: 126.11
• SMILES: C1=COC(=C1)C(=O)NN
• Topological: 68.3
• Monoisotopic Mass: 126.042927438
• Synonyms: 3326-71-4, 2-Furoic acid hydrazide, 2-Furoic hydrazide, 2-Furohydrazide, 2-Furancarbohydrazide, 2-Furoylhydrazide, 2-Furancarboxylic acid, hydrazide, Furoic acid, hydrazide, 2-Furylcarbonylhydrazide, 2-Furancarbohydrazonic acid, 2-FUROIC ACID, HYDRAZIDE, Pyromucic acid hydrazide, 2-Furancarbonyl hydrazide, 2-Furylcarboxylic acid hydrazide, NSC 11957, NSC 35574, EINECS 222-046-2, BRN 0114435, AI3-62534, DTXSID10186900, 5-18-06-00125 (Beilstein Handbook Reference), DTXCID10109391, 2-Furancarboxylic acid, hydrazide (9CI), 222-046-2, furan-2-carbohydrazide, Furoylhydrazide, 2-furancarboxylic acid hydrazide, MFCD00003235, Furan-2-carboxylic acid hydrazide, WLN: T5OJ BVMZ, NSC11957, NSC35574, Furancarboxylic acid, hydrazide, 2-furanhydrazide, 2-Furoichydrazide, 2-furanoic hydrazide, furan 2-carbohydrazide, 2-Furoic hydrazide, 98%, SCHEMBL140989, CHEMBL340492, SCHEMBL11590839, HMS1775C18, CS-M1764, NSC-11957, NSC-35574, SBB028222, STK121925, AKOS000194881, FF02859, AS-57679, SY048471, DB-048376, DB-293084, F1015, NS00029450, ST45028837, 2-Furoic hydrazide, purum, >=97.0% (NT), EN300-17784, F10405, AN-068/40170015, Z57036326, F3145-4915, InChI=1/C5H6N2O2/c6-7-5(8)4-2-1-3-9-4/h1-3H,6H2,(H,7,8

Application

2-Furoic acid hydrazide serves as a key building block in medicinal chemistry for the design of hydrazone-based therapeutics, particularly in antitubercular and antiviral drug discovery. Its reactive hydrazide group facilitates Schiff base formation, enabling covalent conjugation with aldehydes/ketones for bioactive scaffold development. Researchers also employ it as a precursor for synthesizing fused heterocycles like oxadiazoles, which exhibit notable pharmacological properties. In material science, it acts as a crosslinking agent for polymer modifications.

Safety and Hazards

GHS Hazard Statements

• H302 (87.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (87.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (87.5%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (87.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.