Description

2-Hydroxy-5-(trifluoromethyl)pyridine (CAS No. 33252-63-0) is a high-purity fluorinated pyridine derivative with the molecular formula C₆H₄F₃NO. This compound, also known by its IUPAC name 5-(trifluoromethyl)-1H-pyridin-2-one, features a hydroxyl group at the 2-position and a trifluoromethyl group at the 5-position of the pyridine ring, offering unique electronic and steric properties. Its molecular weight is 163.10 g/mol, and it is supplied as a white to off-white crystalline powder with ≥98% purity (HPLC). Ideal for pharmaceutical intermediates, agrochemical synthesis, and material science applications, this compound is packaged under inert gas to ensure stability and longevity. Store in a cool, dry place away from light and moisture.

Properties

• CAS Number: 33252-63-0
• Complexity: 239
• IUPAC Name: 5-(trifluoromethyl)-1H-pyridin-2-one
• InChI: InChI=1S/C6H4F3NO/c7-6(8,9)4-1-2-5(11)10-3-4/h1-3H,(H,10,11)
• InChI Key: BYRJSCNPUHYZQE-UHFFFAOYSA-N
• Exact Mass: 163.02449824
• Molecular Formula: C6H4F3NO
• Molecular Weight: 163.10
• SMILES: C1=CC(=O)NC=C1C(F)(F)F
• Topological: 29.1
• Monoisotopic Mass: 163.02449824
• Synonyms: 33252-63-0, 2-Hydroxy-5-(trifluoromethyl)pyridine, 2(1H)-Pyridinone, 5-(trifluoromethyl)-, 2H-5TFMP, 5-(Trifluoromethyl)-2(1H)-pyridinone, 1CCP81H07B, TRIFLUOROMETHYL)-2(1H)-PYRIDINONE, 5-(, 627-625-7, 2-Hydroxy-5-trifluoromethylpyridine, 5-(trifluoromethyl)pyridin-2-ol, 5-(trifluoromethyl)-1H-pyridin-2-one, 5-(Trifluoromethyl)-2-pyridinol, MFCD00042315, 5-(Trifluoromethyl)-2-pyridone, 5-trifluoromethyl-pyridin-2-ol, 79894-13-6, 5-(Trifluoromethyl)pyridin-2(1H)-one, 5-(trifluoromethyl)-1,2-dihydropyridin-2-one, 5-(trifluoromethyl)pyridin-2-one, Maybridge1_006426, UNII-1CCP81H07B, 5-trifluoromethyl-2-pyridone, 5-trifluoromethylpyrid-2-one, 5-trifluoromethyl-2-pyridinol, SCHEMBL525257, SCHEMBL609810, SCHEMBL1450952, SCHEMBL2147015, SCHEMBL4859976, SCHEMBL9901679, SCHEMBL9901726, CHEMBL5424775, DTXSID8044387, Fluazifop-P-butyl metabolite 10, HMS559M02, 5-(Trifluoromethyl)-2-pyridinone, JUVOJLXGVHWBEO-UHFFFAOYSA-N, YZUQZFUCRSLKEN-UHFFFAOYSA-N, 5-(trifluoromethyl) pyridin-2-ol, 5-trifluoromethyl-2(1h)-pyridone, CS-B0101, 5-(trifloromethyl)-2(1H)-pyridone, BBL100558, CCG-49593, RB1047, SBB055714, STL554352, 5-trifluoromethyl-2-(1h)-pyridinone, 5-(trifluoromethyl)hydropyridin-2-one, AKOS001054750, AKOS005145592, 5-(trifluoromethyl)-2-(1H)-pyridone, AC-9476, FS-2555, BP-20272, SY007020, 5-TRIFLUOROMETHYL-2-HYDROXYPYRIDINE, DB-021192, 2-Hydroxy-5-(trifluoromethyl)pyridine, 97%, NS00016194, ST50407040, T2539, EN300-05018, 5E-502, SR-01000639040-1, Q27252234, Z56910389, U4D

Application

2-Hydroxy-5-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry for the synthesis of trifluoromethyl-containing bioactive molecules. It is employed in the development of kinase inhibitors and antiviral agents due to its electron-withdrawing trifluoromethyl group. In agrochemical research, it acts as a key intermediate for herbicides and fungicides. The compound’s unique structure also makes it valuable in material science for designing fluorinated polymers and liquid crystals.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.