Description

2-Chloro-3-fluoro-4-formylpyridine (CAS No. 329794-28-7) is a high-purity heterocyclic aldehyde with the molecular formula C₆H₃ClFNO. This compound, also known as 2-chloro-3-fluoropyridine-4-carbaldehyde, is a versatile building block in pharmaceutical and agrochemical synthesis. Its unique structure, featuring both chloro and fluoro substituents adjacent to a reactive formyl group, enables selective modifications for advanced intermediate development. Supplied as a crystalline solid with ≥95% purity (HPLC), it is rigorously tested for consistency, stability, and low heavy metal content. Ideal for cross-coupling reactions, nucleophilic additions, and heterocyclic expansions. Packaged under inert gas in amber glass vials to ensure longevity and shipped with comprehensive analytical data (NMR, MS, HPLC).

Properties

• CAS Number: 329794-28-7
• Complexity: 133
• IUPAC Name: 2-chloro-3-fluoro-pyridine-4-carbaldehyde
• InChI: InChI=1S/C6H3ClFNO/c7-6-5(8)4(3-10)1-2-9-6/h1-3H
• InChI Key: RWSUDYQQHLWWDK-UHFFFAOYSA-N
• Exact Mass: 158.9887196
• Molecular Formula: C6H3ClFNO
• Molecular Weight: 159.54
• SMILES: C1=CN=C(C(=C1C=O)F)Cl
• Topological: 30
• Monoisotopic Mass: 158.9887196
• Synonyms: 329794-28-7, 2-CHLORO-3-FLUORO-4-FORMYLPYRIDINE, 2-Chloro-3-fluoroisonicotinaldehyde, 2-chloro-3-fluoropyridine-4-carbaldehyde, 2-Chloro-3-fluoropyridine-4-carboxaldehyde, 2-Chloro-3-fluoropyridine-4-carboxaldehye, MFCD04972388, 2-chloro-3-fluoro-pyridine-4-carbaldehyde, 4-PYRIDINECARBOXALDEHYDE, 2-CHLORO-3-FLUORO-, SCHEMBL1637824, DTXSID60376773, RWSUDYQQHLWWDK-UHFFFAOYSA-N, BBL101493, STL555289, AKOS005259208, AB20966, PS-8785, AC-33405, SY022336, DB-006040, CS-0007512, EN300-159956, 2-Chloro-3-fluoropyridine-4-carboxaldehyde, 97%

Application

This compound serves as a key intermediate in the synthesis of fluorinated pyridine derivatives for drug discovery, particularly in kinase inhibitor development. Its reactive aldehyde group facilitates Schiff base formation for bioactive molecule construction. Researchers utilize it in Suzuki-Miyaura couplings to create complex heterocyclic scaffolds. The electron-withdrawing halogen substituents enhance its utility in nucleophilic aromatic substitution reactions.

Safety and Hazards

GHS Hazard Statements

• H302 (97.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.5%)
• Eye Irrit. 2A (100%)

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