Description

(S)-1,2,3,4-Tetrahydro-1-naphthylamine Hydrochloride (CAS: 32908-42-2) is a high-purity chiral amine hydrochloride derivative widely used in pharmaceutical research and organic synthesis. This compound, with the molecular formula C₁₀H₁₄ClN, is an enantiomerically pure building block essential for asymmetric synthesis and drug development. Its tetralin-based structure makes it a valuable intermediate for the preparation of bioactive molecules, particularly in central nervous system (CNS) targeting compounds.

Supplied as a white to off-white crystalline powder, this reagent is characterized by its high chemical stability and consistent performance in reactions such as reductive amination, nucleophilic substitution, and chiral resolution. The hydrochloride salt form enhances its solubility in polar solvents, facilitating its use in aqueous reaction conditions. Each batch undergoes rigorous quality control, including HPLC and chiral purity analysis, to ensure >98% chemical and enantiomeric purity.

Packaged under inert atmosphere to prevent degradation, this product is ideal for medicinal chemistry applications where stereochemical control is critical. Available in research quantities from milligrams to multi-gram scale, with custom synthesis options available for bulk requirements. SDS and analytical certificates provided with every shipment.

Properties

• CAS Number: 32908-42-2
• Complexity: 133
• IUPAC Name: (1S)-tetralin-1-amine;hydrochloride
• InChI: InChI=1S/C10H13N.ClH/c11-10-7-3-5-8-4-1-2-6-9(8)10;/h1-2,4,6,10H,3,5,7,11H2;1H/t10-;/m0./s1
• InChI Key: DETWFIUAXSWCIK-PPHPATTJSA-N
• Exact Mass: 183.0814771
• Molecular Formula: C10H14ClN
• Molecular Weight: 183.68
• SMILES: C1C[C@@H](C2=CC=CC=C2C1)N.Cl
• Topological: 26
• Monoisotopic Mass: 183.0814771
• Synonyms: 32908-42-2, (S)-1,2,3,4-Tetrahydro-1-naphthylamine Hydrochloride, (S)-1,2,3,4-Tetrahydronaphthalen-1-amine hydrochloride, (S)–1-AMINOTETRALINE HCL, (1S)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride, (1S)-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride, (S)-1,2,3,4-Tetrahydro-1-Naphthylamine HCl, MFCD09996883, SCHEMBL1874441, (S)-1-AMINOTETRALINE HCL, AKOS016016506, EN300-6487477, (S)-1,2,3,4-Tetrahydronaphthalen-1-aminehydrochloride

This chiral amine hydrochloride serves as a key intermediate in the synthesis of pharmacologically active compounds, particularly those targeting serotonin and dopamine receptors. Researchers utilize it in asymmetric synthesis of tetralin-based drug candidates for neurological disorders. The compound’s rigid structure makes it valuable for studying stereospecific enzyme interactions. It’s also employed in the development of chiral catalysts for enantioselective transformations.

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