Description

2,5-Bis(trifluoromethyl)aniline (CAS: 328-93-8) is a high-purity fluorinated aromatic amine with the molecular formula C₈H₅F₆N. This compound features two trifluoromethyl groups positioned at the 2 and 5 positions of the aniline ring, enhancing its electron-withdrawing properties and making it a valuable intermediate in advanced organic synthesis. With a purity of ≥99%, it is ideal for pharmaceutical, agrochemical, and materials science applications where precise fluorination is required. Its stable structure ensures compatibility with a wide range of reaction conditions, including coupling reactions, nucleophilic substitutions, and catalytic transformations. Packaged under inert gas to prevent degradation, this product is rigorously tested via GC, NMR, and HPLC to meet the stringent demands of research and industrial laboratories.

Properties

• CAS Number: 328-93-8
• Complexity: 220
• IUPAC Name: 2,5-bis(trifluoromethyl)aniline
• InChI: InChI=1S/C8H5F6N/c9-7(10,11)4-1-2-5(6(15)3-4)8(12,13)14/h1-3H,15H2
• InChI Key: XWMVIJUAZAEWIE-UHFFFAOYSA-N
• Exact Mass: 229.03261814
• Molecular Formula: C8H5F6N
• Molecular Weight: 229.12
• SMILES: C1=CC(=C(C=C1C(F)(F)F)N)C(F)(F)F
• Topological: 26
• Monoisotopic Mass: 229.03261814
• Synonyms: 2,5-Bis(trifluoromethyl)aniline, 328-93-8, DTXSID00352132, DTXCID90303198, 629-040-2, uiwvoubvgbjrnp-uhfffaoysa-n, 2,5-di(trifluoromethyl)aniline, 2,5-bis-(Trifluoromethyl)aniline, 2,5-bis-trifluoromethylaniline, 2,5-Bis(trifluoromethyl)-aniline, 2,5-BIS(TRIFLUOROMETHYL)BENZENAMINE, MFCD00074940, 2,5-bis(trifluoromethyl)phenylamine, Benzenamine, 2,5-bis(trifluoromethyl)-, alpha,alpha,alpha,alphaatrade mark,alphaatrade mark,alphaatrade mark-hexafluoro-2,5-Xylidine; 2,5-Bis(trifluoromethyl)aniline; 2,5-Bis(trifluoromethyl)benzenamine; 2,5-Di(trifluoromethyl)aniline; alpha,alpha,alpha,alpha’,alpha’,alpha’-hexafluoro-2,5-Xylidine, alpha,alpha,alpha,alpha’,alpha’,alpha’-Hexafluoro-2,5-xylidine, Enamine_005232, 2,5-bis-trifluoromethylanilin, SCHEMBL330502, SCHEMBL5841906, 2,5-bis-trifluoromethyl-aniline, HMS1408N18, BCP08855, 2,5-Bis (trifluoro methyl) aniline, SBB000691, AKOS000115443, AC-3652, CS-W007922, PS-7734, 2,5-Bis(trifluoromethyl)aniline, 99%, IDI1_007819, DB-013161, B2544, NS00126766, ST51040180, EN300-02439, A821499, Z56896763

2,5-Bis(trifluoromethyl)aniline is widely used as a key building block in the synthesis of pharmaceuticals, particularly for introducing trifluoromethyl groups into bioactive molecules to enhance metabolic stability and lipophilicity. It serves as a precursor in the development of agrochemicals, such as herbicides and fungicides, leveraging its electron-deficient aromatic ring for targeted reactivity. In materials science, it contributes to the creation of specialty polymers and liquid crystals with unique thermal and optical properties. Researchers also employ it in palladium-catalyzed cross-coupling reactions to construct complex fluorinated architectures.

Safety and Hazards

GHS Hazard Statements

• H302 (91.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (89.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (91.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (91.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (89.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (78.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (10.7%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (91.1%)
• Acute Tox. 4 (89.3%)
• Skin Irrit. 2 (91.1%)
• Eye Irrit. 2 (91.1%)
• Acute Tox. 4 (89.3%)
• STOT SE 3 (78.6%)
• STOT RE 2 (10.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.