Description

Pyridine Hydrofluoride (1:1) is a highly specialized chemical reagent widely utilized in organic synthesis and fluorination reactions. This anhydrous complex, composed of pyridine and hydrogen fluoride in a 1:1 molar ratio, offers a safer and more controlled alternative to pure hydrogen fluoride due to its reduced volatility and moderated reactivity. With the molecular formula C₅H₆FN and CAS number 32001-55-1, it is commonly referred to as Olah’s Reagent, named after the Nobel laureate George A. Olah who pioneered its use. The reagent is particularly valued for its ability to facilitate electrophilic fluorination, deprotection of silyl ethers, and as a catalyst in various transformations. Available in high-purity grades, it is packaged under inert conditions to ensure stability and longevity. Ideal for research laboratories and industrial applications requiring precise fluorination.

Properties

• CAS Number: 32001-55-1
• Complexity: 30.9
• IUPAC Name: pyridine;hydrofluoride
• InChI: InChI=1S/C5H5N.FH/c1-2-4-6-5-3-1;/h1-5H;1H
• InChI Key: GRJJQCWNZGRKAU-UHFFFAOYSA-N
• Exact Mass: 99.048427358
• Molecular Formula: C5H6FN
• Molecular Weight: 99.11
• SMILES: C1=CC=NC=C1.F
• Topological: 12.9
• Monoisotopic Mass: 99.048427358
• Synonyms: Pyridine hydrofluoride, 32001-55-1, Pyridinium fluoride, Pyridine, hydrofluoride (1:1), EINECS 250-889-6, DTXSID3067653, Hydrogen fluoride, pyridine reagent, anhydrous, DTXCID7038444, 250-889-6, Hydrogen Fluoride-Pyridine, 62778-11-4, Olah’s Reagent, pyridine;hydrofluoride, Pyridine, hydrofluoride, Hydrogen fluoride pyridine, HF-Pyridine, Hydrogen fluoride-pyridine (70% HF), Hydrogen Fluoride-Pyridine;62778-11-4, HF.pyridine, Pyridine-hydrofluoride, hydrofluoric acid pyridine, hydrogen fluoride/pyridine, pyridine hydrogen fluoride, SCHEMBL97170, 71398-22-6, WS725Z8FJ7, BCP24413, MFCD00012436, AKOS005254489, AKOS005254545, AKOS005254546, AKOS005254547, BP-31048, DB-048138, D78350, F0001-0956, Hydrogen fluoride pyridine, pyridine ~30 %, hydrogen fluoride ~70 %

Pyridine Hydrofluoride is extensively used as a fluorinating agent in organic synthesis, particularly for converting alcohols to alkyl fluorides. It serves as a mild and selective reagent for deprotecting tert-butyldimethylsilyl (TBDMS) ethers without affecting other functional groups. Additionally, it is employed in the synthesis of fluorinated pharmaceuticals and agrochemicals due to its controlled reactivity. The reagent is also utilized in polymer chemistry for modifying surfaces and creating fluorine-containing polymers. Its stability and ease of handling make it a preferred choice over anhydrous hydrogen fluoride in many laboratory settings.

Safety and Hazards

GHS Hazard Statements

• H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
• H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]

Precautionary Statements

• P260, P262, P264, P270, P271, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P320, P321, P330, P361+P364, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 1 (93.3%)
• Acute Tox. 1 (93.3%)
• Skin Corr. 1B (100%)
• Acute Tox. 1 (93.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.