Description

1-Bromo-5-fluoronaphthalene (CAS No. 315-56-0) is a high-purity halogenated naphthalene derivative with the molecular formula C₁₀H₆BrF. This compound is characterized by its bromine and fluorine substituents on the naphthalene ring, making it a versatile intermediate for organic synthesis, pharmaceuticals, and materials science research. It is supplied as a crystalline solid with >98% purity (HPLC) and is rigorously tested for consistency, ensuring optimal performance in cross-coupling reactions, Suzuki-Miyaura couplings, and other organometallic applications. Ideal for researchers seeking a stable, reactive building block for advanced heterocyclic chemistry.

Properties

• CAS Number: 315-56-0
• Complexity: 160
• IUPAC Name: 1-bromo-5-fluoro-naphthalene
• InChI: InChI=1S/C10H6BrF/c11-9-5-1-4-8-7(9)3-2-6-10(8)12/h1-6H
• InChI Key: ZYBZDDMAAQTLEV-UHFFFAOYSA-N
• Exact Mass: 223.96369
• Molecular Formula: C10H6BrF
• Molecular Weight: 225.06
• SMILES: C1=CC2=C(C=CC=C2Br)C(=C1)F
• Monoisotopic Mass: 223.96369
• Synonyms: 1-Bromo-5-fluoronaphthalene, 315-56-0, DTXSID60504195, DTXCID90455005, 859-100-5, MFCD09258916, 1-bromo-5-fluoro-naphthalene, 5-bromo-1-fluoronaphthalene, SCHEMBL4106168, SCHEMBL16586285, ZYBZDDMAAQTLEV-UHFFFAOYSA-N, SBB096775, AKOS022185698, AS-47031, SY204700, DB-363477, CS-0155711, EN300-244315, F11594, Z1269237310

Application

1-Bromo-5-fluoronaphthalene is widely used as a key synthon in the preparation of fluorinated polycyclic aromatic hydrocarbons (PAHs) and liquid crystal materials. Its electron-deficient naphthalene core facilitates palladium-catalyzed cross-coupling reactions, enabling the synthesis of complex organic frameworks. Researchers also employ it in the development of fluorescent probes and pharmaceutical intermediates due to its unique halogenated structure.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.