Description

2-Fluoro-2-methylpropan-1-ol (CAS No. 3109-99-7) is a high-purity fluorinated alcohol with the molecular formula C₄H₉FO. This specialized chemical is designed for advanced research and industrial applications, offering exceptional reactivity due to its fluorine substitution at the 2-position. The compound is synthesized under stringent quality controls to ensure >98% purity (GC), making it suitable for pharmaceutical intermediates, agrochemical synthesis, and material science research. Its unique steric and electronic properties make it a valuable building block for modifying molecular scaffolds. Packaged in amber glass bottles under inert atmosphere to ensure stability, this product is ideal for researchers requiring precise fluorination effects in their synthetic pathways.

Properties

• CAS Number: 3109-99-7
• Complexity: 42.8
• IUPAC Name: 2-fluoro-2-methyl-propan-1-ol
• InChI: InChI=1S/C4H9FO/c1-4(2,5)3-6/h6H,3H2,1-2H3
• InChI Key: VQDNMKWCOYVVJH-UHFFFAOYSA-N
• Exact Mass: 92.063743068
• Molecular Formula: C4H9FO
• Molecular Weight: 92.11
• SMILES: CC(C)(CO)F
• Topological: 20.2
• Monoisotopic Mass: 92.063743068
• Synonyms: 2-Fluoro-2-methylpropan-1-ol, 3109-99-7, DTXSID70456030, DTXCID80406849, 631-135-9, 2-fluoro-2-methyl-propan-1-ol, 2-Fluoro-2-methyl-1-propanol, 1-Propanol, 2-fluoro-2-methyl-, 1-Propanol,2-fluoro-2-methyl-, MFCD09030962, 2,2-Dimethyl-2-fluoroethanol, SCHEMBL384171, SCHEMBL384172, SCHEMBL19411969, VQDNMKWCOYVVJH-UHFFFAOYSA-N, CS-D1107, AKOS006289362, FF61487, AS-60046, DA-26205, SY029466, EN300-170305, P17817, F8888-1563

Application

2-Fluoro-2-methylpropan-1-ol serves as a key fluorinated synthon in pharmaceutical development, particularly for introducing fluorine into bioactive molecules to enhance metabolic stability. It is employed in asymmetric synthesis as a chiral auxiliary and finds use in polymer chemistry as a modifier for surface energy. The compound’s reactivity also makes it valuable in nucleophilic substitution reactions for agrochemical research.

Safety and Hazards

GHS Hazard Statements

• H302 (97.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (46.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H319 (51.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (46.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P321, P330, P337+P317, P362+P364, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.5%)
• Acute Tox. 4 (46.2%)
• Eye Irrit. 2A (51.2%)
• Acute Tox. 4 (46.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.