Description

DL-Thyroxine (CAS 300-30-1) is a synthetic racemic mixture of the thyroid hormone thyroxine, with the molecular formula C₁₅H₁₁I₄NO₄. This compound is chemically defined as 2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid, featuring four iodine atoms critical for its biological activity. DL-Thyroxine is widely utilized in biochemical and pharmaceutical research, particularly in studies involving thyroid function, hormone metabolism, and receptor binding assays. Available in high-purity form, this product is rigorously tested for quality, ensuring consistency for laboratory and research applications. Suitable for use in in vitro and in vivo studies, it is provided as a lyophilized powder or in solution for ease of use.

Properties

• CAS Number: 300-30-1
• Complexity: 420
• IUPAC Name: 2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoic acid
• InChI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)
• InChI Key: XUIIKFGFIJCVMT-UHFFFAOYSA-N
• Exact Mass: 776.6867
• Molecular Formula: C15H11I4NO4
• Molecular Weight: 776.87
• SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N
• Topological: 92.8
• Monoisotopic Mass: 776.6867
• Synonyms: DL-Thyroxine, 300-30-1, Thyroxine, dl-, 2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid, CHEBI:30660, QR0BV3BRIA, O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-DL-tyrosine, Levothyroxine;T4, 2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic acid, 2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoic acid, D-T4; D-Thyroxine, UNII-QR0BV3BRIA, THX, EINECS 206-088-9, Monosodium thyroxine, T4 (pharmaceutical), Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, DL-THYROXINE [MI], Epitope ID:122661, SCHEMBL26147, CHEMBL42115, SGCUT00139, 3,5,5′-Tetraiodo-L-thyronine, DTXSID0023662, BDBM398048, HMS3656A22, HMS5081H09, US10322118, Entry 6, ALBB-014128, BCP34411, SYB78014, to_000083, NSC259940, SBB072358, STL481965, AKOS003348790, AKOS016344683, HY-W415287, NCGC00094852-01, NCGC00094852-02, NCGC00094852-04, 7488-70-2, L-Tyrosine,5-diiodophenyl)-3,5-diiodo-, LS-04434, DB-230290, NS00075564, dl-O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine, DL-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, L-Tyrosine,5-diiodophenyl)-3,5-diiodo-, monosodium salt, (.+/-.)-O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine, 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylalanine #, (+/-)-3-(4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL)ALANINE

Application

DL-Thyroxine is primarily used in research to study thyroid hormone signaling, metabolic regulation, and endocrine disorders. It serves as a reference standard in analytical methods such as HPLC and LC-MS for quantifying thyroxine levels in biological samples. Researchers also employ it to investigate the effects of thyroid hormone analogs in cell culture and animal models.

Safety and Hazards

GHS Hazard Statements

• H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P264, P270, P319, and P501

Hazard Classes and Categories

• STOT RE 1 (100%)

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