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Atomfair 2,5-Difluorobenzoic acid C7H4F2O2 CAS 2991-28-8

2,5-Difluorobenzoic Acid (CAS No. 2991-28-8) is a high-purity fluorinated aromatic carboxylic acid with the molecular formula C7H4F2O2. This compound is a versatile building block in organic synthesis, pharmaceutical research, and material science applications. Its structure features two fluorine atoms at the 2- and 5-positions of the benzoic acid ring, enhancing its reactivity and utility in cross-coupling reactions, derivatization, and as a precursor for advanced intermediates. Available in >98% purity (HPLC), this product is supplied as a white to off-white crystalline powder, packaged under inert conditions to ensure stability. Ideal for researchers requiring precise fluorinated compounds for drug discovery, agrochemical development,…

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Description

2,5-Difluorobenzoic Acid (CAS No. 2991-28-8) is a high-purity fluorinated aromatic carboxylic acid with the molecular formula C7H4F2O2. This compound is a versatile building block in organic synthesis, pharmaceutical research, and material science applications. Its structure features two fluorine atoms at the 2- and 5-positions of the benzoic acid ring, enhancing its reactivity and utility in cross-coupling reactions, derivatization, and as a precursor for advanced intermediates. Available in >98% purity (HPLC), this product is supplied as a white to off-white crystalline powder, packaged under inert conditions to ensure stability. Ideal for researchers requiring precise fluorinated compounds for drug discovery, agrochemical development, or liquid crystal synthesis.

Properties

  • CAS Number: 2991-28-8
  • Complexity: 161
  • IUPAC Name: 2,5-difluorobenzoic acid
  • InChI: InChI=1S/C7H4F2O2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11)
  • InChI Key: LBQMIAVIGLLBGW-UHFFFAOYSA-N
  • Exact Mass: 158.01793569
  • Molecular Formula: C7H4F2O2
  • Molecular Weight: 158.10
  • SMILES: C1=CC(=C(C=C1F)C(=O)O)F
  • Topological: 37.3
  • Monoisotopic Mass: 158.01793569
  • Physical Description: White, odorless crystalline powder;
  • Synonyms: 2,5-Difluorobenzoic acid, 2991-28-8, Benzoic acid, 2,5-difluoro-, EINECS 221-060-6, NSC 190310, LBQMIAVIGLLBGW-UHFFFAOYSA-, DTXSID30184024, DTXCID40106515, 221-060-6, inchi=1/c7h4f2o2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3h,(h,10,11), lbqmiavigllbgw-uhfffaoysa-n, 2,5-difluoro-benzoic acid, MFCD00002410, NSC-190310, NSC 190310;, NSC190310, GF8ZKM9RKS, SCHEMBL115334, SCHEMBL23931623, 2,5-Difluorobenzoic acid, 98%, BCP24598, SBB063429, STK802570, AKOS000122998, AC-3949, BS-3868, CS-W020593, FD64200, SY009582, DB-023877, D1699, NS00020628, ST50824667, EN300-18709, Z89265799

Application

2,5-Difluorobenzoic acid is widely used as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty materials. Its fluorinated aromatic structure makes it valuable in the development of active pharmaceutical ingredients (APIs) and ligands for catalysis. Researchers also employ it in the preparation of liquid crystals and polymers with tailored electronic properties. The compound’s reactivity enables efficient derivatization for probing structure-activity relationships in medicinal chemistry.

Safety and Hazards

GHS Hazard Statements

  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2 (100%)
  • STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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