Description

3,3,3-Trifluoropropylamine hydrochloride (CAS No. 2968-33-4) is a high-purity fluorinated organic compound with the molecular formula C₃H₇ClF₃N. This white to off-white crystalline powder is widely used in pharmaceutical and agrochemical research due to its trifluoropropyl moiety, which enhances bioavailability and metabolic stability. With a molecular weight of 149.54 g/mol, it is soluble in polar solvents such as water, methanol, and ethanol. Ideal for nucleophilic substitution reactions, this reagent is rigorously tested for quality (≥98% purity by HPLC) and is supplied in sealed packaging under inert conditions to ensure stability. Suitable for lab-scale synthesis, medicinal chemistry, and material science applications.

Properties

• CAS Number: 2968-33-4
• Complexity: 48.6
• IUPAC Name: 3,3,3-trifluoropropan-1-amine;hydrochloride
• InChI: InChI=1S/C3H6F3N.ClH/c4-3(5,6)1-2-7;/h1-2,7H2;1H
• InChI Key: IGOPOYHPIKTQSS-UHFFFAOYSA-N
• Exact Mass: 149.0219114
• Molecular Formula: C3H7ClF3N
• Molecular Weight: 149.54
• SMILES: C(CN)C(F)(F)F.Cl
• Topological: 26
• Monoisotopic Mass: 149.0219114
• Synonyms: 3,3,3-Trifluoropropylamine hydrochloride, 1-Propanamine, 3,3,3-trifluoro-, hydrochloride (1:1), 671-581-1, 2968-33-4, 3,3,3-trifluoropropan-1-amine hydrochloride, C3H7ClF3N, MFCD00236725, 3,3,3-Trifluoro-1-propylamine Hydrochloride, 3,3,3-trifluoropropan-1-amine;hydrochloride, SCHEMBL458653, 3,3,3-Trifluoropropylamine, HCl, 3,3,3-Trifluoro-n-propylamine hydrochloride, 1-Propanamine, 3,3,3-trifluoro-, hydrochloride, 3,3,3-TRIFLUOROPROPAN-1-AMINE HCL, DTXSID30649103, SBB086667, 3,3,3-trifluoropropylamine, chloride, AKOS005063897, CS-W004765, SB75656, DS-14869, SY031710, 3,3,3-trifluoro-propylamine hydrochloride, (3,3,3-trifluoropropyl)amine hydrochloride, 3,3,3-trifluoropropan-1-aminehydrochloride, DB-047628, 3-Amino-1,1,1-trifluoropropane hydrochloride, EN300-41781, P15354, 3,3,3-Trifluoro-1-propanamine hydrochloride, AldrichCPR, Z1741959014, 3,3,3-Trifluoropropan-1-amine–hydrogen chloride (1/1)

Application

3,3,3-Trifluoropropylamine hydrochloride is a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of protease inhibitors and CNS-active compounds. Its trifluoromethyl group improves lipophilicity and binding affinity in drug candidates. Researchers also utilize it in agrochemical formulations to enhance pesticide efficacy. Additionally, it serves as a building block for specialty polymers and surfactants with unique hydrophobic properties.

Safety and Hazards

GHS Hazard Statements

• H302 (90.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (90.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (90.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (90.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (90.9%)
• Skin Irrit. 2 (90.9%)
• Eye Irrit. 2A (90.9%)
• STOT SE 3 (90.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.