Description

2-Chloronicotinic Acid (CAS No. 2942-59-8) is a high-purity organic compound with the molecular formula C₆H₄ClNO₂ and IUPAC name 2-chloropyridine-3-carboxylic acid. This fine chemical is a versatile building block in pharmaceutical and agrochemical synthesis, featuring a chlorinated pyridine ring with a carboxylic acid functional group. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline powder with excellent batch-to-batch consistency. Suitable for nucleophilic substitution reactions, metal-catalyzed cross-couplings, and heterocyclic transformations. Packaged under inert gas in amber glass bottles with multiple seals to ensure stability and longevity. Ideal for medicinal chemistry, material science research, and as a precursor for active pharmaceutical ingredients (APIs).

Properties

• CAS Number: 2942-59-8
• Complexity: 140
• IUPAC Name: 2-chloropyridine-3-carboxylic acid
• InChI: InChI=1S/C6H4ClNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H,9,10)
• InChI Key: IBRSSZOHCGUTHI-UHFFFAOYSA-N
• Exact Mass: 156.9930561
• Molecular Formula: C6H4ClNO2
• Molecular Weight: 157.55
• SMILES: C1=CC(=C(N=C1)Cl)C(=O)O
• Topological: 50.2
• Monoisotopic Mass: 156.9930561
• Synonyms: 2-Chloronicotinic acid, 2-Chloropyridine-3-carboxylic acid, 2-Chloro-3-pyridinecarboxylic acid, 3-Pyridinecarboxylic acid, 2-chloro-, 2-Chloro-nicotinic acid, Nicotinic acid, 2-chloro-, 3-Carboxy-2-chloropyridine, NSC 378, NSC-378, UNII-93G386213F, EINECS 220-937-0, 93G386213F, DTXSID9062726, EC 220-937-0, 3-PYRIDINECARBOXYLIC ACID,2-CHLORO, FLUNIXIN MEGLUMINE IMPURITY A [EP IMPURITY], FLUNIXIN MEGLUMINE IMPURITY A (EP IMPURITY), DTXCID6037984, 220-937-0, ibrsszohcguthi-uhfffaoysa-n, inchi=1/c6h4clno2/c7-5-4(6(9)10)2-1-3-8-5/h1-3h,(h,9,10, 2942-59-8, MFCD00006236, 2-chloro nicotinic acid, 2-Chloronicotinicacid, chloronicotinic acid, 2chloronicotinic acid, CNIS, 2-choronicotinic acid, Niflumic acid impurity A, MLS000332085, SCHEMBL353141, NSC378, CHEMBL1505789, SCHEMBL17180592, SCHEMBL28089157, 2-chloropyridin-3-carboxylic acid, CHEBI:194658, HMS2619A03, 2-chloropyridine 3-carboxylic acid, BCP27191, 2-chloro-pyridine-3-carboxylic acid, SBB004002, STK394287, AKOS000119897, AB00651, AC-2515, CS-W017965, FC37673, HY-W017249, M510M47, PS-5333, SB40463, NCGC00246335-01, BP-11743, PD014281, SMR000221567, SY001758, 2-Chloropyridine-3-carboxylic acid, 99%, DB-005235, NS00006996, ST50214355, EN300-19633, P16536, AC-907/30003060, Q27271592, F2191-0179, Z104474538, Niflumic acid impurity A, European Pharmacopoeia (EP) Reference Standard, 960360-14-9

Application

2-Chloronicotinic acid serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of pyridine-based drug candidates. It is widely used in Suzuki-Miyaura and other cross-coupling reactions to create biaryl structures for medicinal chemistry applications. The compound also finds use in agrochemical research for creating novel pesticides and herbicides with improved efficacy.

Safety and Hazards

GHS Hazard Statements

• H315 (14.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (91.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (13.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (14.7%)
• Eye Irrit. 2 (91.2%)
• STOT SE 3 (13.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.