Description

5-Bromo-2-fluoro-3-methylpyridine (CAS No. 29312-98-9) is a high-purity halogenated pyridine derivative with the molecular formula C₆H₅BrFN. This compound is a valuable building block in pharmaceutical and agrochemical synthesis, offering versatile reactivity for cross-coupling reactions, nucleophilic substitutions, and metal-catalyzed transformations. Its unique structure, featuring bromine and fluorine substituents on a methylated pyridine ring, enables precise functionalization for advanced heterocyclic chemistry. Supplied as a crystalline solid with ≥95% purity (GC), it is rigorously tested by HPLC, NMR, and mass spectrometry to ensure batch-to-batch consistency. Packaged under inert gas in amber glass vials to prevent degradation, this product is ideal for high-throughput screening and process R&D.

Properties

• CAS Number: 29312-98-9
• Complexity: 99.1
• IUPAC Name: 5-bromo-2-fluoro-3-methyl-pyridine
• InChI: InChI=1S/C6H5BrFN/c1-4-2-5(7)3-9-6(4)8/h2-3H,1H3
• InChI Key: JLCVSFDCHKCISN-UHFFFAOYSA-N
• Exact Mass: 188.95894
• Molecular Formula: C6H5BrFN
• Molecular Weight: 190.01
• SMILES: CC1=CC(=CN=C1F)Br
• Topological: 12.9
• Monoisotopic Mass: 188.95894
• Synonyms: 5-Bromo-2-fluoro-3-methylpyridine, 29312-98-9, DTXSID10476611, DTXCID10427421, 642-599-7, 5-Bromo-2-fluoro-3-picoline, 2-fluoro-5-bromo-3-methylpyridine, PYRIDINE, 5-BROMO-2-FLUORO-3-METHYL-, MFCD03095091, SCHEMBL502626, JLCVSFDCHKCISN-UHFFFAOYSA-N, 3-Bromo-6-fluoro-5-methylpyridine, BCP22184, CS-D0944, 5-bromo-2-fluoro-3-methyl pyridine, BBL100742, SBB091029, STL554536, AKOS005255549, AB13475, AC-3134, FB08156, PS-8391, SY003968, DB-023875, B3775, 5-Bromo-2-fluoro-3-methylpyridine, AldrichCPR, EN300-157891, 5-Bromo-2-fluoro-3-picoline (5-Bromo-2-fluoro-3-methylpyridine), 2-Fluoro-5-bromo-3-methylpyridine ;5-Bromo-2-fluoro-3-methylpyridine

Application

5-Bromo-2-fluoro-3-methylpyridine serves as a key intermediate in the synthesis of biologically active molecules, particularly in the development of kinase inhibitors and antimicrobial agents. Its bromine moiety facilitates Suzuki-Miyaura couplings for biaryl construction, while the fluorine atom enhances metabolic stability in drug candidates. Researchers utilize this compound to engineer crop protection chemicals targeting pest-specific enzymes. The methyl group at the 3-position allows further derivatization via C-H activation strategies.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (87.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (87.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.