Description

5-Bromo-2-chloro-3-methylpyridine (CAS No. 29241-60-9) is a high-purity halogenated pyridine derivative with the molecular formula C₆H₅BrClN. This compound is widely utilized as a key intermediate in pharmaceutical synthesis, agrochemical production, and advanced material research. Its unique structure, featuring bromo, chloro, and methyl functional groups on the pyridine ring, enables selective reactivity for cross-coupling reactions, nucleophilic substitutions, and other transformations critical to fine chemical manufacturing. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline solid with excellent shelf stability under recommended storage conditions (2-8°C in inert atmosphere). Suitable for research and development applications requiring precise molecular building blocks, this compound is packaged under nitrogen in amber glass vials to ensure maximum stability during transport and storage. Technical specifications include: molecular weight 206.47 g/mol, density ~1.6 g/cm³, melting point 45-50°C, and boiling point 250-255°C. Available in research quantities (100mg to 10g) with bulk options upon request.

Properties

• CAS Number: 29241-60-9
• Complexity: 99.1
• IUPAC Name: 5-bromo-2-chloro-3-methyl-pyridine
• InChI: InChI=1S/C6H5BrClN/c1-4-2-5(7)3-9-6(4)8/h2-3H,1H3
• InChI Key: YTSKHJMMNFPBBZ-UHFFFAOYSA-N
• Exact Mass: 204.92939
• Molecular Formula: C6H5BrClN
• Molecular Weight: 206.47
• SMILES: CC1=CC(=CN=C1Cl)Br
• Topological: 12.9
• Monoisotopic Mass: 204.92939
• Synonyms: 5-bromo-2-chloro-3-methylpyridine, DTXSID50301312, DTXCID00252446, 691-306-9, 29241-60-9, 2-chloro-3-methyl-5-bromopyridine, 5-Bromo-2-chloro-3-picoline, Pyridine, 5-bromo-2-chloro-3-methyl-, MFCD03095093, 5-bromo-2-chloro-3-methyl pyridine, 5-bromo-2-chloro-3-methyl-pyridine, NSC142312, SCHEMBL652596, SCHEMBL20304858, YTSKHJMMNFPBBZ-UHFFFAOYSA-N, 5-Bromo-2-chloro-3-picoline (5-Bromo-2-chloro-3-methylpyridine), BCP22181, CS-D0945, BBL104280, SBB013901, STL558480, AKOS005258276, AC-7014, NSC-142312, PS-8072, SY002697, DB-008186, B3744, EN300-130742, 5-Bromo-2-Chloro-3-methylpyridine;5-Bromo-3-methyl-2-Chloropyridine;2-Chloro-3-methyl-5-bromopyridine;2-Chloro-5-bromo-3-methylpyridine

5-Bromo-2-chloro-3-methylpyridine serves as a versatile precursor in Suzuki-Miyaura and Stille cross-coupling reactions for pharmaceutical intermediates. It finds application in the synthesis of biologically active compounds including kinase inhibitors and antimicrobial agents. The compound’s halogenated pyridine structure makes it valuable for constructing complex heterocycles in medicinal chemistry programs. Researchers also employ it as a building block for crop protection chemicals and functional materials development.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.