Description

Potassium Trifluoroacetate (CAS No. 2923-16-2) is a high-purity inorganic salt with the molecular formula C₂F₃KO₂, widely used in organic synthesis and pharmaceutical research. This white crystalline powder is highly soluble in water and polar organic solvents, making it an excellent reagent for nucleophilic trifluoromethylation reactions. Its IUPAC name, potassium;2,2,2-trifluoroacetate, reflects its trifluoroacetate anion structure, which is pivotal in introducing trifluoromethyl groups into complex molecules. With a purity of ≥98%, our Potassium Trifluoroacetate is rigorously tested for trace metals and moisture content, ensuring optimal performance in sensitive applications. Suitable for use as a catalyst, ligand, or precursor in fluorination reactions, this compound is packaged under inert conditions to guarantee stability and shelf life.

Properties

• CAS Number: 2923-16-2
• Complexity: 87.8
• IUPAC Name: potassium;2,2,2-trifluoroacetate
• InChI: InChI=1S/C2HF3O2.K/c3-2(4,5)1(6)7;/h(H,6,7);/q;+1/p-1
• InChI Key: CUNPJFGIODEJLQ-UHFFFAOYSA-M
• Exact Mass: 151.94874521
• Molecular Formula: C2F3KO2
• Molecular Weight: 152.11
• SMILES: C(=O)(C(F)(F)F)[O-].[K+]
• Topological: 40.1
• Monoisotopic Mass: 151.94874521
• Synonyms: Potassium trifluoroacetate, 2923-16-2, EINECS 220-877-5, DTXSID00951841, EC 220-877-5, DTXCID601379949, 220-877-5, potassium 2,2,2-trifluoroacetate, Trifluoroacetic acid potassium salt, potassium;2,2,2-trifluoroacetate, Acetic acid, 2,2,2-trifluoro-, potassium salt (1:1), Acetic acid, trifluoro-, potassium salt, potassium,2,2,2-trifluoroacetate, MFCD00013215, C2F3KO2, SCHEMBL108536, Trifluoroacetic acid, potassium salt, SBB086819, AKOS015893280, CS-W018104, AS-68697, potassium 2,2,2-tris(fluoranyl)ethanoate, 2,2,2-trifluoroacetic acid, potassium salt, NS00078267, P2114, D92188, A819828, Q61083505

Application

Potassium Trifluoroacetate is extensively utilized in organic chemistry as a trifluoromethylating agent for synthesizing fluorinated pharmaceuticals and agrochemicals. It serves as a key intermediate in the preparation of bioactive molecules, enhancing their metabolic stability and lipophilicity. Researchers also employ it in peptide synthesis and as a buffer component in biochemical assays. Its compatibility with palladium catalysts makes it valuable in cross-coupling reactions for constructing complex fluorinated architectures.

Safety and Hazards

GHS Hazard Statements

• H300 (49.4%): Fatal if swallowed [Danger Acute toxicity, oral]
• H400 (49.4%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
• H412 (42%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P264, P270, P273, P301+P316, P321, P330, P391, P405, and P501

Hazard Classes and Categories

• Acute Tox. 2 (49.4%)
• Aquatic Acute 1 (49.4%)
• Aquatic Chronic 3 (42%)

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