Description

2-Fluorobenzenesulphonyl chloride (CAS No. 2905-21-7) is a high-purity sulfonyl chloride derivative widely utilized in organic synthesis and pharmaceutical research. This compound, with the molecular formula C₆H₄ClFO₂S, serves as a versatile building block for the introduction of the 2-fluorobenzenesulfonyl moiety into target molecules. Its IUPAC name, 2-fluorobenzenesulfonyl chloride, reflects its precise chemical structure, featuring a reactive sulfonyl chloride group adjacent to a fluorine substituent on the benzene ring. The compound is supplied as a clear to pale yellow liquid (or solid, depending on temperature) and should be stored under inert conditions to prevent hydrolysis. With a molecular weight of 194.61 g/mol, it is particularly valuable for nucleophilic substitution reactions, Suzuki couplings, and as a precursor for sulfonamide formation. Our product is rigorously tested to ensure >98% purity (by GC or HPLC) and is packaged in amber glass bottles under nitrogen to maximize shelf life. Suitable for use in medicinal chemistry, agrochemical development, and material science applications.

Properties

• CAS Number: 2905-21-7
• Complexity: 221
• IUPAC Name: 2-fluorobenzenesulfonyl chloride
• InChI: InChI=1S/C6H4ClFO2S/c7-11(9,10)6-4-2-1-3-5(6)8/h1-4H
• InChI Key: ZSZKAQCISWFDCQ-UHFFFAOYSA-N
• Exact Mass: 193.9604564
• Molecular Formula: C6H4ClFO2S
• Molecular Weight: 194.61
• SMILES: C1=CC=C(C(=C1)F)S(=O)(=O)Cl
• Topological: 42.5
• Monoisotopic Mass: 193.9604564
• Synonyms: 2905-21-7, 2-Fluorobenzenesulphonyl chloride, DTXSID00183286, DTXCID10105777, zszkaqciswfdcq-uhfffaoysa-n, 2-Fluorobenzenesulfonyl chloride, 2-Fluorobenzene-1-Sulfonyl Chloride, BENZENESULFONYL CHLORIDE, 2-FLUORO-, 2-fluoro-benzenesulfonyl chloride, 2-Fluorobenzenesulfonylchloride, MFCD00042285, chloro(2-fluorophenyl)sulfone, 2-fluorophenylsulfonyl chloride, SCHEMBL16412, 2-fluoro-benzenesulfonylchloride, 2-fluoro-benzensulfonyl chloride, 2-Fluorobenzene-sulfonyl chloride, 2-fluorobenzene-1-sulfonylchloride, ALBB-001001, BBL013801, SBB046738, STK500496, AKOS000200661, 2-Fluorobenzenesulfonyl chloride, 97%, CS-W007338, AS-38664, DB-021118, F0795, ST50411832, EN300-04155, F2167-0009

Application

2-Fluorobenzenesulphonyl chloride is primarily employed as a key intermediate in the synthesis of sulfonamide-based pharmaceuticals and bioactive molecules. It finds extensive use in medicinal chemistry for the development of enzyme inhibitors and receptor modulators due to its ability to introduce both fluorine and sulfonyl pharmacophores. The compound is also utilized in the preparation of advanced materials, including liquid crystals and polymers, where the fluorine substituent can modulate electronic properties. Additionally, it serves as a precursor for fluorescent dyes and other specialty chemicals requiring a benzenesulfonyl scaffold.

Safety and Hazards

GHS Hazard Statements

• H302 (43.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (47.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P260, P264, P264+P265, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (43.5%)
• Skin Corr. 1B (100%)
• Eye Dam. 1 (47.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.