Description

Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate (CAS No. 287953-54-2) is a high-purity synthetic organic compound with the molecular formula C₁₃H₁₆ClNO₄S. This specialized chemical features a piperidine core functionalized with a chlorosulfonyl group and a benzyl carboxylate moiety, making it a versatile intermediate for pharmaceutical and biochemical research. With a molecular weight of 317.79 g/mol, it is supplied as a white to off-white crystalline powder, ensuring consistent performance in synthetic applications. Ideal for peptide coupling, sulfonamide formation, and other nucleophilic substitution reactions, this compound is rigorously tested for purity (typically ≥95% by HPLC) and stability. Store in a cool, dry place under inert conditions to maintain optimal shelf life.

Properties

• CAS Number: 287953-54-2
• Complexity: 420
• IUPAC Name: benzyl 4-chlorosulfonylpiperidine-1-carboxylate
• InChI: InChI=1S/C13H16ClNO4S/c14-20(17,18)12-6-8-15(9-7-12)13(16)19-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2
• InChI Key: HEGCWAOVTPVFBJ-UHFFFAOYSA-N
• Exact Mass: 317.0488569
• Molecular Formula: C13H16ClNO4S
• Molecular Weight: 317.79
• SMILES: C1CN(CCC1S(=O)(=O)Cl)C(=O)OCC2=CC=CC=C2
• Topological: 72.1
• Monoisotopic Mass: 317.0488569
• Synonyms: 287953-54-2, benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate, DTXSID50620272, DTXCID80571026, 690-834-7, N-Benzyloxycarbonyl-4-piperidinesulfonyl chloride, benzyl 4-chlorosulfonylpiperidine-1-carboxylate, N-CBZ-4-piperidine sulfonyl chloride, 1-PIPERIDINECARBOXYLIC ACID, 4-(CHLOROSULFONYL)-, PHENYLMETHYL ESTER, MFCD05664659, N-BENZYLOXYCARBONYL-4-PIPERIDINESULFONYLCHLORIDE, N-benzyloxycarbonyl-4-piperidine sulfonyl chloride, N-Cbz-piperidine-4-sulfonyl Chloride, 289030-38-2, SCHEMBL477255, HEGCWAOVTPVFBJ-UHFFFAOYSA-N, N-(BENZYLOXYCARBONYL)-PIPERIDINE-4-SULPHONYL CHLORIDE, 4-chlorosulfonyl-1-piperidinecarboxylic acid (phenylmethyl) ester, ALBB-031196, BENZYL 4-(CHLOROSULFONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE, SBB066429, AKOS015850687, AB22398, AC-9041, CS-W022588, GS-6540, DA-35069, SY033172, DB-027374, EN300-74411, A819600, benzyl-4-(chlorosulfonyl)piperidine-1-carboxylate, phenylmethyl 4-(chlorosulfonyl)piperidinecarboxylate, BENZYL 4-(CHLOROSULFONYL)-1-PIPERIDINECARBOXYLATE, F9995-2347, phenylmethyl 4-(chlorosulfonyl)-1-piperidinecarboxylate, PIPERIDINE-4-SULFONYL CHLORIDE, N-CBZ PROTECTED, (phenylmethyl) 4-chloranylsulfonylpiperidine-1-carboxylate

Application

Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate is primarily used as a key intermediate in the synthesis of sulfonamide-based pharmaceuticals and bioactive molecules. Its reactive chlorosulfonyl group enables efficient conjugation with amines or alcohols to form sulfonamides or sulfonate esters, respectively. Researchers utilize this compound in medicinal chemistry for developing protease inhibitors and CNS-targeting drugs due to its piperidine scaffold. It also serves as a precursor for advanced polymer and material science applications requiring sulfonyl-functionalized building blocks.

Safety and Hazards

GHS Hazard Statements

• H314 (66.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H335 (33.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P264, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P321, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (66.7%)
• STOT SE 3 (33.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.