Description

(4-Ethoxy-3-fluorophenyl)boronic acid (CAS: 279263-10-4) is a high-purity boronic acid derivative widely used in organic synthesis, pharmaceuticals, and materials science. With the molecular formula C₈H₁₀BFO₃, this compound serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds in complex molecular architectures. It is supplied as a white to off-white crystalline powder with varying amounts of anhydride, ensuring compatibility with rigorous laboratory and industrial applications. Ideal for researchers in medicinal chemistry and catalysis, this reagent is meticulously packaged under inert conditions to maintain stability and performance. Store in a cool, dry place away from moisture to preserve its reactivity.

Properties

• CAS Number: 279263-10-4
• Complexity: 156
• IUPAC Name: (4-ethoxy-3-fluoro-phenyl)boronic acid
• InChI: InChI=1S/C8H10BFO3/c1-2-13-8-4-3-6(9(11)12)5-7(8)10/h3-5,11-12H,2H2,1H3
• InChI Key: ZONJMULNQBNBGU-UHFFFAOYSA-N
• Exact Mass: 184.0707025
• Molecular Formula: C8H10BFO3
• Molecular Weight: 183.97
• SMILES: B(C1=CC(=C(C=C1)OCC)F)(O)O
• Topological: 49.7
• Monoisotopic Mass: 184.0707025
• Synonyms: (4-ethoxy-3-fluorophenyl)boronic acid, 805-284-7, 4-Ethoxy-3-fluorophenylboronic acid, 279263-10-4, 4-Ethoxy-3-fluorobenzeneboronic acid, MFCD04115667, 4-Ethoxy-3-fluorophenylboronic Acid (contains varying amounts of Anhydride), 4-Ethoxy-3-fluorophenylboronicacid, Boronic acid, (4-ethoxy-3-fluorophenyl)-, 3-fluoro-4-ethoxyphenyl boronic acid, (4-ethoxy-3-fluoro)phenylboronic acid, SCHEMBL8351, DTXSID70382320, ZONJMULNQBNBGU-UHFFFAOYSA-N, 3-fluoro-4-ethoxyphenylboronic acid, 3-Fluoro-4-ethoxybenzeneboronic acid, SBB071260, AKOS004119245, CS-W017023, PS-9526, SY017914, DB-028857, E1124, I12374, EN300-2613269, Z1255458150

(4-Ethoxy-3-fluorophenyl)boronic acid is primarily employed in Suzuki-Miyaura cross-coupling reactions to synthesize biaryl compounds, a key step in pharmaceutical intermediates. It is also utilized in the development of fluorinated organic materials and sensors due to its unique electronic properties. Researchers leverage its stability and reactivity for constructing complex molecules in drug discovery and agrochemical research.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.