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Atomfair 2-Bromo-3-iodopyridine C5H3BrIN CAS 265981-13-3

2-Bromo-3-iodopyridine (CAS No. 265981-13-3) is a high-purity halogenated pyridine derivative with the molecular formula C5H3BrIN . This heteroaromatic compound is a valuable building block in pharmaceutical and agrochemical synthesis, offering dual reactivity for selective functionalization at both bromo and iodo sites. Its crystalline solid form ensures consistent handling and stoichiometric accuracy in reactions. Ideal for cross-coupling reactions (e.g., Suzuki, Stille, Negishi), this reagent is rigorously tested via GC/MS and NMR to meet ≥98% purity standards. Packaged under inert gas to enhance shelf stability, it is supplied in amber glass vials to prevent photodegradation.

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Description

2-Bromo-3-iodopyridine (CAS No. 265981-13-3) is a high-purity halogenated pyridine derivative with the molecular formula C5H3BrIN. This heteroaromatic compound is a valuable building block in pharmaceutical and agrochemical synthesis, offering dual reactivity for selective functionalization at both bromo and iodo sites. Its crystalline solid form ensures consistent handling and stoichiometric accuracy in reactions. Ideal for cross-coupling reactions (e.g., Suzuki, Stille, Negishi), this reagent is rigorously tested via GC/MS and NMR to meet ≥98% purity standards. Packaged under inert gas to enhance shelf stability, it is supplied in amber glass vials to prevent photodegradation.

Properties

  • CAS Number: 265981-13-3
  • Complexity: 78.8
  • IUPAC Name: 2-bromo-3-iodo-pyridine
  • InChI: InChI=1S/C5H3BrIN/c6-5-4(7)2-1-3-8-5/h1-3H
  • InChI Key: FZBHCYSESMFQJL-UHFFFAOYSA-N
  • Exact Mass: 282.84936
  • Molecular Formula: C5H3BrIN
  • Molecular Weight: 283.89
  • SMILES: C1=CC(=C(N=C1)Br)I
  • Topological: 12.9
  • Monoisotopic Mass: 282.84936
  • Synonyms: 2-Bromo-3-iodopyridine, 265981-13-3, DTXSID10463506, DTXCID00414325, 631-088-4, Pyridine, 2-bromo-3-iodo-, MFCD09056782, 2-bromo-3-iodo-pyridine, 3-Iodo-2-bromopyridine, SCHEMBL487404, SCHEMBL1996521, FZBHCYSESMFQJL-UHFFFAOYSA-N, AKOS016003411, CS-W014001, GS-5627, MB06974, SY022373, DB-023860, B5201, EN300-119736, doi:10.14272/FZBHCYSESMFQJL-UHFFFAOYSA-N.1

Application

2-Bromo-3-iodopyridine serves as a versatile intermediate in medicinal chemistry for constructing kinase inhibitors and antiviral agents. Its orthogonal halogen substituents enable sequential palladium-catalyzed couplings to generate complex biaryl scaffolds. Researchers utilize this compound in isotopic labeling studies (13C/15N) due to its predictable reactivity. It is also employed in materials science for synthesizing electron-deficient π-conjugated systems in OLED development.

Safety and Hazards

GHS Hazard Statements

  • H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H318 (97.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
  • H400 (97.6%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

Precautionary Statements

  • P264, P264+P265, P270, P273, P280, P301+P317, P305+P354+P338, P317, P330, P391, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (97.6%)
  • Eye Dam. 1 (97.6%)
  • Aquatic Acute 1 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

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Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

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  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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