Description

2,3-Difluoro-4-methoxyphenol (CAS No. 261763-29-5) is a high-purity fluorinated phenolic compound with the molecular formula C₇H₆F₂O₂. This specialty chemical is characterized by its unique structural features, including two fluorine substituents and a methoxy group on the aromatic ring, making it a valuable intermediate in synthetic organic chemistry and pharmaceutical research. Its IUPAC name is 2,3-difluoro-4-methoxyphenol, and it is supplied as a fine white to off-white crystalline powder with a purity of ≥98% (HPLC). Suitable for use in nucleophilic aromatic substitution reactions, cross-coupling reactions, and as a building block for advanced materials, this compound is rigorously tested for quality and consistency. Packaged under inert gas to ensure stability, it is ideal for researchers requiring precise fluorinated precursors.

Properties

• CAS Number: 261763-29-5
• Complexity: 132
• IUPAC Name: 2,3-difluoro-4-methoxy-phenol
• InChI: InChI=1S/C7H6F2O2/c1-11-5-3-2-4(10)6(8)7(5)9/h2-3,10H,1H3
• InChI Key: CKKAZWYLHGNVDZ-UHFFFAOYSA-N
• Exact Mass: 160.03358575
• Molecular Formula: C7H6F2O2
• Molecular Weight: 160.12
• SMILES: COC1=C(C(=C(C=C1)O)F)F
• Topological: 29.5
• Monoisotopic Mass: 160.03358575
• Synonyms: 2,3-Difluoro-4-methoxyphenol, 261763-29-5, DTXSID00378892, DTXCID90329919, Phenol, 2,3-difluoro-4-methoxy-, MFCD01631505, 2,3-Difluoro-4-methoxy-phenol, SCHEMBL714254, CKKAZWYLHGNVDZ-UHFFFAOYSA-N, SBB055465, AKOS006228774, CS-W016169, AC-14524, DA-18214, SY101222, TS-02120, 2,3-Difluoro-4-methoxyphenol, AldrichCPR, ST50826629, EN300-6769398

Application

2,3-Difluoro-4-methoxyphenol is widely utilized as a key intermediate in the synthesis of fluorinated pharmaceuticals, agrochemicals, and liquid crystal materials. Its electron-withdrawing fluorine atoms enhance reactivity in palladium-catalyzed cross-coupling reactions, making it valuable for constructing complex aromatic systems. Researchers also employ this compound in the development of novel bioactive molecules due to its ability to modulate lipophilicity and metabolic stability.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (20%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (80%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (20%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (20%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (20%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (20%)
• Acute Tox. 4 (20%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.