Description

Boric Acid Pinacol Ester (CAS No. 25240-59-9) is a high-purity organoboron compound with the molecular formula C₆H₁₃BO₃. Also known as 2-hydroxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, this versatile reagent is widely utilized in organic synthesis, catalysis, and as a boron source in cross-coupling reactions. Its stable cyclic ester structure makes it an excellent precursor for Suzuki-Miyaura couplings, hydroboration, and other transition-metal-catalyzed transformations. This product is rigorously tested for purity and consistency, ensuring optimal performance in research and industrial applications. Suitable for use under inert conditions, it is supplied in moisture-resistant packaging to maintain integrity.

Properties

• CAS Number: 25240-59-9
• Complexity: 128
• IUPAC Name: 2-hydroxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• InChI: InChI=1S/C6H13BO3/c1-5(2)6(3,4)10-7(8)9-5/h8H,1-4H3
• InChI Key: ZZPNDIHOQDQVNU-UHFFFAOYSA-N
• Exact Mass: 144.0957744
• Molecular Formula: C6H13BO3
• Molecular Weight: 143.98
• SMILES: B1(OC(C(O1)(C)C)(C)C)O
• Topological: 38.7
• Monoisotopic Mass: 144.0957744
• Synonyms: Boric acid, pinacol ester, 800-445-8, 25240-59-9, 2-hydroxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, Boric acid pinacol ester, 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-ol, 4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-OL, 1,3,2-Dioxaborolane, 2-hydroxy-4,4,5,5-tetramethyl-, J2YVW7NQB5, tetramethyl-1,3,2-dioxaborolan-2-ol, NSC-638835, 2,3-Butanediol, 2,3-dimethyl-, cyclic borate, 2,3-Butanediol, 2,3-dimethyl-, cyclic ester with boric acid (H3BO3), 2-Hydroxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; NSC 638835; Cyclic Borate 2,3-Dimethyl-2,3butanediol;, NSC638835, Crisaborole Impurity 3, UNII-J2YVW7NQB5, SCHEMBL5074935, 2-Hydroxy-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane, CHEMBL1965861, DTXSID00327249, ZZPNDIHOQDQVNU-UHFFFAOYSA-N, Hydroxo(2,3-diolato)borone(III), MFCD15143603, AKOS006334179, BS-27771, FB160522, NCI60_012959, CS-0176800, F77069

Application

Boric Acid Pinacol Ester is commonly employed as a boronating agent in Suzuki-Miyaura cross-coupling reactions, enabling the synthesis of biaryl compounds. It serves as a key intermediate in pharmaceutical and agrochemical research due to its stability and reactivity. Additionally, it is used in polymer chemistry and materials science for modifying organic frameworks with boron-containing functional groups.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.