Description

2-Carbomethoxypyridine (CAS No. 2459-07-6), also known as methyl pyridine-2-carboxylate, is a high-purity organic compound with the molecular formula C₇H₇NO₂. This versatile ester derivative of picolinic acid is widely utilized in pharmaceutical synthesis, agrochemical research, and coordination chemistry. The compound presents as a clear to pale yellow liquid with a characteristic aromatic odor, offering excellent solubility in common organic solvents such as ethanol, methanol, and dichloromethane. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in amber glass bottles under inert atmosphere to guarantee stability. Ideal for use as a building block in heterocyclic chemistry, 2-Carbomethoxypyridine serves as a key intermediate for the preparation of various bioactive molecules and metal-organic frameworks (MOFs).

Key Specifications:
– Molecular Weight: 137.14 g/mol
– Boiling Point: 220-222°C
– Density: 1.12 g/cm³
– Refractive Index: n²⁰_D 1.508-1.512
– Storage Conditions: 2-8°C under nitrogen

Properties

• CAS Number: 2459-07-6
• Complexity: 125
• IUPAC Name: methyl pyridine-2-carboxylate
• InChI: InChI=1S/C7H7NO2/c1-10-7(9)6-4-2-3-5-8-6/h2-5H,1H3
• InChI Key: NMMIHXMBOZYNET-UHFFFAOYSA-N
• Exact Mass: 137.047678466
• Molecular Formula: C7H7NO2
• Molecular Weight: 137.14
• SMILES: COC(=O)C1=CC=CC=N1
• Topological: 39.2
• Monoisotopic Mass: 137.047678466
• Synonyms: Methyl picolinate, 2459-07-6, Methyl pyridine-2-carboxylate, 2-Pyridinecarboxylic acid, methyl ester, 2-Picolinic acid methyl ester, Methyl 2-pyridinecarboxylate, Picolinic acid, methyl ester, 2-Carbomethoxypyridine, II4AAE7Y3A, 2-(Methoxycarbonyl)pyridine, NSC-1459, DTXSID4062432, NSC 1459, EINECS 219-545-2, DTXCID0037102, Picolinic acid, methyl ester (8CI), Methyl pyridine-2-carboxylate; 2-Carbomethoxypyridine, Pyridine-2-carboxylic acid methyl ester, methylpicolinate, Picolinic Acid Methyl Ester, MFCD00038038, carbomethoxypyridine, 2-Pyridinecarboxylic acid methyl ester, Methyl picolinate, 99%, UNII-II4AAE7Y3A, METHYL-2-PICOLINATE, pyridine, 2-methoxycarbonyl-, SCHEMBL126083, SCHEMBL127671, SCHEMBL128093, SCHEMBL128329, SCHEMBL247011, SCHEMBL597214, CHEMBL309354, NSC1459, CHEBI:167765, BCP25790, s6317, SBB008127, AKOS000567519, CS-W005458, GS-3031, HY-W005458, AC-22483, PD123983, SY005022, DB-012703, NS00015528, P0423, ST50828295, EN300-49544, O11979, Q63398035, Z19673259, F0001-0835, InChI=1/C7H7NO2/c1-10-7(9)6-4-2-3-5-8-6/h2-5H,1H

Application

2-Carbomethoxypyridine is extensively employed as a versatile synthon in medicinal chemistry for constructing pyridine-based pharmacophores. Researchers utilize this compound as a ligand precursor in catalytic systems and as a starting material for synthesizing nicotinic acid derivatives. In material science, it finds application in the development of coordination polymers and as a modifier for surface functionalization. The ester functionality makes it particularly valuable for prodrug development and controlled-release formulations in pharmaceutical research.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.6%)

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