Description

4-Amino-3,5-dichlorobenzotrifluoride (CAS No. 24279-39-8) is a high-purity halogenated aniline derivative with the molecular formula C₇H₄Cl₂F₃N. This compound, also known by its IUPAC name 2,6-dichloro-4-(trifluoromethyl)aniline, features a trifluoromethyl group and two chlorine atoms positioned ortho to the amino group, making it a versatile intermediate for organic synthesis and pharmaceutical applications. Its unique structure offers excellent reactivity for nucleophilic substitution and coupling reactions. Available in >98% purity (HPLC), this chemical is supplied as a crystalline solid with strict quality control to ensure consistency for research and industrial use. Store under inert conditions at 2-8°C to maintain stability.

Properties

• CAS Number: 24279-39-8
• Complexity: 173
• IUPAC Name: 2,6-dichloro-4-(trifluoromethyl)aniline
• InChI: InChI=1S/C7H4Cl2F3N/c8-4-1-3(7(10,11)12)2-5(9)6(4)13/h1-2H,13H2
• InChI Key: ITNMAZSPBLRJLU-UHFFFAOYSA-N
• Exact Mass: 228.9672890
• Molecular Formula: C7H4Cl2F3N
• Molecular Weight: 230.01
• SMILES: C1=C(C=C(C(=C1Cl)N)Cl)C(F)(F)F
• Topological: 26
• Monoisotopic Mass: 228.9672890
• Synonyms: 24279-39-8, 4-Amino-3,5-dichlorobenzotrifluoride, 2,6-dichloro-4-trifluoromethylaniline, DTXSID30179011, EC 416-430-0, DTXCID60101502, 416-430-0, 607-349-3, 2,6-Dichloro-4-(trifluoromethyl)aniline, 3,5-dichloro-4-aminobenzotrifluoride, 2,6-dichloro-4-(trifluoromethyl)phenylamine, MFCD00052918, 3,5-dichloro-4-amino benzotrifluoride, BENZENAMINE, 2,6-DICHLORO-4-(TRIFLUOROMETHYL)-, Toluidine, 2,6-dichloro-a,a,a-trifluoro- (8CI); 2,6-Dichloro-4-(trifluoromethyl)benzenamine; 2,6-Dichloro-4-trifluoromethylaniline; 4-Amino-3,5-dichlorobenzotrifluoride, SCHEMBL967220, 2,6-DICHLORO-4-(TRIFLUOROMETHYL)-BENZENAMINE, SCHEMBL6378825, SBB003283, 2,6-dichlor-4-trifluoromethyl aniline, AKOS015850198, AC-6882, AS-9317, CS-W010384, FD37282, 2,6-dichloro-4-trifluoromethyl-aniline, 4-(trifluoromethyl)-2,6-dichloroaniline, 2,6-Dichloro-4-trifluoromethylphenylamine, A1900, NS00003390, ST50307891, 2,6-Dichloro-4-(trifluoromethyl)aniline, 99%, A21508, EN300-153243, 2,6-Dichloro-4-trifluoromethyl aniline;2,6-Dichloro-4-trifluoromethylaniline;, InChI=1/C7H4Cl2F3N/c8-4-1-3(7(10,11)12)2-5(9)6(4)13/h1-2H,13H

Application

4-Amino-3,5-dichlorobenzotrifluoride serves as a key building block in agrochemical and pharmaceutical synthesis, particularly for herbicides and fungicides targeting resistant strains. Its electron-withdrawing trifluoromethyl group enhances the bioactivity of derived compounds. Researchers also utilize it in material science to develop fluorinated polymers with enhanced thermal and chemical resistance. The compound’s reactivity makes it valuable for creating dyes and advanced intermediates in cross-coupling reactions.

Safety and Hazards

GHS Hazard Statements

• H302: Harmful if swallowed [Warning Acute toxicity, oral]
• H315: Causes skin irritation [Warning Skin corrosion/irritation]
• H317: May cause an allergic skin reaction [Warning Sensitization, Skin]
• H332: Harmful if inhaled [Warning Acute toxicity, inhalation]
• H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P261, P264, P270, P271, P272, P273, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P332+P317, P333+P317, P362+P364, P391, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (99.1%)
• Skin Sens. 1 (100%)
• Acute Tox. 4 (100%)
• Aquatic Acute 1 (99.1%)
• Aquatic Chronic 1 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.