Description

2-Fluoro-5-methylpyridine (CAS: 2369-19-9) is a high-purity fluorinated pyridine derivative with the molecular formula C₆H₆FN. This heterocyclic compound is characterized by a fluorine substituent at the 2-position and a methyl group at the 5-position of the pyridine ring, offering unique reactivity for advanced synthetic applications. It is supplied as a clear, colorless to pale yellow liquid with ≥98% purity (GC), ideal for pharmaceutical intermediates, agrochemical synthesis, and ligand design in catalysis. Store under inert atmosphere at 2-8°C to maintain stability. Packaged in amber glass bottles with secure seals to ensure integrity during transit. Available in research (5g, 25g) and bulk (100g, 1kg) quantities with optional COA/MSDS documentation.

Properties

• CAS Number: 2369-19-9
• Complexity: 74.9
• IUPAC Name: 2-fluoro-5-methyl-pyridine
• InChI: InChI=1S/C6H6FN/c1-5-2-3-6(7)8-4-5/h2-4H,1H3
• InChI Key: AOSOZARHUJMBLZ-UHFFFAOYSA-N
• Exact Mass: 111.048427358
• Molecular Formula: C6H6FN
• Molecular Weight: 111.12
• SMILES: CC1=CN=C(C=C1)F
• Topological: 12.9
• Monoisotopic Mass: 111.048427358
• Synonyms: 2-Fluoro-5-methylpyridine, 2369-19-9, DTXSID60379143, DTXCID70330169, 624-867-5, aosozarhujmblz-uhfffaoysa-n, Pyridine, 2-fluoro-5-methyl-, 6-Fluoro-3-picoline, 2-Fluoro-5-picoline, MFCD00041225, 2-fluoro-5-methyl-pyridine, 5-methyl-2-fluoropyridine, 6-fluoro-3-methylpyridine, 2-fluoro-5-methyl pyridine, SCHEMBL114511, SCHEMBL447044, SCHEMBL675543, SCHEMBL3056334, SCHEMBL4756471, 2-Fluoro-5-methylpyridine, 97%, BCP22107, AKOS005064125, AB01857, CS-W019967, PS-9259, DB-031386, A4945, F0581, EN300-90409, F11222, 2-Fluoro-5-methylpyridine (2-Fluoro-5-picoline)

Application

2-Fluoro-5-methylpyridine serves as a versatile building block in medicinal chemistry for the synthesis of fluorinated drug candidates, particularly kinase inhibitors and CNS-targeting compounds. Its electron-withdrawing fluorine enhances reactivity in cross-coupling reactions (e.g., Suzuki-Miyaura), while the methyl group facilitates further functionalization. The compound is also employed in crop protection chemical development and as a precursor for specialty ligands in transition metal catalysis.

Safety and Hazards

GHS Hazard Statements

• H226 (97.9%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (97.9%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.