Description

5-Fluoro-2-nitroaniline (CAS No. 2369-11-1) is a high-purity fluorinated nitroaniline derivative with the molecular formula C₆H₅FN₂O₂. This aromatic compound features a fluorine substituent at the 5-position and a nitro group at the 2-position of the aniline ring, making it a versatile intermediate for organic synthesis and pharmaceutical research. Its crystalline form ensures excellent stability under standard laboratory conditions. Ideal for researchers in medicinal chemistry, 5-Fluoro-2-nitroaniline is rigorously tested for purity (typically ≥98% by HPLC or GC analysis) and is supplied in secure, light-resistant packaging to prevent degradation. Store in a cool, dry place away from oxidizing agents.

Properties

• CAS Number: 2369-11-1
• Complexity: 159
• IUPAC Name: 5-fluoro-2-nitro-aniline
• InChI: InChI=1S/C6H5FN2O2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H,8H2
• InChI Key: PEDMFCHWOVJDNW-UHFFFAOYSA-N
• Exact Mass: 156.03350557
• Molecular Formula: C6H5FN2O2
• Molecular Weight: 156.11
• SMILES: C1=CC(=C(C=C1F)N)[N+](=O)[O-]
• Topological: 71.8
• Monoisotopic Mass: 156.03350557
• Synonyms: 5-Fluoro-2-nitroaniline, 2369-11-1, Benzenamine, 5-fluoro-2-nitro-, 5-fluoro-2-nitrophenylamine, 5-FLUORO-2-NITROBENZENAMINE, 8QHM7S3T84, NSC-10292, DTXSID80178352, EINECS 219-128-5, NSC 10292, DTXCID10100843, 219-128-5, 2-Nitro-5-fluoroaniline, 2-Amino-4-fluoronitrobenzene, MFCD00034065, 3-FLUORO-6-NITROANILINE, NSC10292, 5-fluro-2-nitrophenylamine, UNII-8QHM7S3T84, SCHEMBL77039, 5-fluoro-2-nitro-phenylamine, 1-amino-3-fluoro-6-nitrobenzene, BCP21691, SBB063162, AKOS005215747, AC-3694, CCG-302553, CS-W001110, FF37677, GS-3014, BP-11249, DB-023639, F0789, NS00049334, EN300-57201, A19765, Z600398356

Application

5-Fluoro-2-nitroaniline is widely used as a key building block in the synthesis of agrochemicals, dyes, and pharmaceutical compounds, particularly in the development of fluorinated heterocycles. Its reactive nitro and amino groups facilitate coupling reactions, making it valuable for creating complex aromatic structures. Researchers also employ it in the study of enzyme inhibition and as a precursor for fluorescent probes in biochemical assays.

Safety and Hazards

GHS Hazard Statements

• H301+H311+H331 (84.4%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H301 (93.3%): Toxic if swallowed [Danger Acute toxicity, oral]
• H311 (93.3%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (11.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (11.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (93.3%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H373 (88.9%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
• H412 (88.9%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (93.3%)
• Acute Tox. 3 (93.3%)
• Skin Irrit. 2 (11.1%)
• Eye Irrit. 2 (11.1%)
• Acute Tox. 3 (93.3%)
• STOT RE 2 (88.9%)
• Aquatic Chronic 3 (88.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.