Description

4-Fluoro-3-(trifluoromethyl)aniline (CAS No. 2357-47-3) is a high-purity fluorinated aromatic amine with the molecular formula C₇H₅F₄N. This compound is a versatile intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and advanced materials. Its unique structure, featuring both a fluorine and a trifluoromethyl group on the aromatic ring, enhances its reactivity and utility in cross-coupling reactions, nucleophilic substitutions, and as a building block for complex molecules. Suitable for researchers and industrial applications, our product is rigorously tested to ensure ≥98% purity (GC), with low levels of impurities. Available in various quantities, packaged under inert gas to maintain stability. Store in a cool, dry place away from light and moisture.

Properties

• CAS Number: 2357-47-3
• Complexity: 156
• IUPAC Name: 4-fluoro-3-(trifluoromethyl)aniline
• InChI: InChI=1S/C7H5F4N/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3H,12H2
• InChI Key: PGFQDLOMDIBAPY-UHFFFAOYSA-N
• Exact Mass: 179.03581181
• Molecular Formula: C7H5F4N
• Molecular Weight: 179.11
• SMILES: C1=CC(=C(C=C1N)C(F)(F)F)F
• Topological: 26
• Monoisotopic Mass: 179.03581181
• Synonyms: 4-Fluoro-3-(trifluoromethyl)aniline, 2357-47-3, 5-Amino-2-fluorobenzotrifluoride, Benzenamine, 4-fluoro-3-(trifluoromethyl)-, 3-Trifluoromethyl-4-fluoroaniline, alpha,alpha,alpha,4-Tetrafluoro-m-toluidine, 4-Fluoro-3-(trifluoromethyl)benzenamine, EINECS 219-095-7, UNII-V5584X2CTL, V5584X2CTL, 2-Fluoro-5-aminobenzotrifluoride, 3-amino-6-fluorobenzotrifluoride, 4-fluoro-3-trifluoromethylphenylamine, NSC-10326, alpha,alpha,alpha-4-Tetrafluoro-m-toluidine, DTXSID1022184, PGFQDLOMDIBAPY-UHFFFAOYSA-, NSC 10326, m-Toluidine, .alpha.,.alpha.,.alpha.,4-tetrafluoro-, 3-TRIFLUOROMETHYL-4-FLUOROPHENYLAMINE, .alpha.,.alpha.,.alpha.,4-Tetrafluoro-m-toluidine, .ALPHA.,.ALPHA.,.ALPHA.,4-TETRAFLUORO-3-METHYLANILINE, DTXCID402184, m-Toluidine, alpha,alpha,alpha,4-tetrafluoro-, ALPHA,ALPHA,ALPHA,4-TETRAFLUORO-3-METHYLANILINE, inchi=1/c7h5f4n/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3h,12h2, pgfqdlomdibapy-uhfffaoysa-n, 4-Fluoro-3-trifluoromethylaniline, 4-fluoro-3-(trifluoromethyl)phenylamine, 4-Tetrafluoro-m-toluidine, NSC10326, MFCD00007834, SCHEMBL146397, SCHEMBL25397850, 4-floro-3-trifloromethyl aniline, a,a,a,4-Tetrafluoro-m-toluidine, 4-fluoro-3-trifloromethyl aniline, 4-fluoro-3-trifluoromethyl aniline, 4-fluoro-3-trifluoromethyl-aniline, ALBB-010362, SBB028385, 4-fluoro-3-(trifluoromethyl) aniline, 4-fluoro-3-(trifluoromethyl)-aniline, AKOS005172622, AC-2636, CS-W020711, PS-8549, 4-fluoro-3-(trifluoromethyl)benzeneamine, 4-Fluoro-3-(trifluoromethyl)aniline, 99%, DB-023838, A1164, NS00049513, ST45027665, EN300-50846, Q27291542, F2190-0479, alpha,alpha,alpha,4-Tetrafluoro-m-toluidine;4-fluoro-3- trifluoromethyl aniline

Application

4-Fluoro-3-(trifluoromethyl)aniline is widely used as a key intermediate in the synthesis of pharmaceuticals, including bioactive molecules and drug candidates. Its fluorinated aromatic structure makes it valuable in agrochemical research for developing herbicides and pesticides. Additionally, it serves as a precursor in materials science for creating specialty polymers and liquid crystals with enhanced thermal and chemical resistance.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (89.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (97.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (87.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (89.4%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (97.9%)
• STOT SE 3 (87.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.