Description

3-Fluoro-5-methoxyaniline (CAS No. 2339-58-4) is a high-purity fluorinated aromatic amine with the molecular formula C₇H₈FNO. This compound is a valuable building block in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and advanced materials. Its unique structure, featuring both a fluorine substituent and a methoxy group on the aniline ring, enables precise modulation of electronic and steric properties in target molecules. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC), with stringent controls for residual solvents and heavy metals. Supplied as a light-sensitive, off-white to pale yellow crystalline powder, it is packaged under inert gas to maintain stability. Ideal for researchers in medicinal chemistry, this compound is available in quantities ranging from grams to kilograms, with custom synthesis options available.

Properties

• CAS Number: 2339-58-4
• Complexity: 110
• IUPAC Name: 3-fluoro-5-methoxy-aniline
• InChI: InChI=1S/C7H8FNO/c1-10-7-3-5(8)2-6(9)4-7/h2-4H,9H2,1H3
• InChI Key: BHWSRJOKTBUWBN-UHFFFAOYSA-N
• Exact Mass: 141.058992041
• Molecular Formula: C7H8FNO
• Molecular Weight: 141.14
• SMILES: COC1=CC(=CC(=C1)N)F
• Topological: 35.3
• Monoisotopic Mass: 141.058992041
• Synonyms: 3-Fluoro-5-methoxyaniline, 2339-58-4, DTXSID00654284, DTXCID00605034, 831-710-6, Benzenamine, 3-fluoro-5-methoxy-, 3-Amino-5-fluoroanisole, MFCD00077535, 3-fluoro-5-methoxy-aniline, 5-Fluoro-m-anisidine, 3-methoxy-5-fluoroaniline, 3-fluoro-5-methoxybenzenamine, 3-fluoro-5-methoxyphenylamine, SCHEMBL112833, 3-fluoranyl-5-methoxy-aniline, BHWSRJOKTBUWBN-UHFFFAOYSA-N, SBB086189, AKOS006345207, CS-W002330, PS-9021, SY026956, 3-Amino-5-fluoroanisole, 5-Fluoro-m-anisidine, EN300-107071, A816699, Z1201618813

Application

3-Fluoro-5-methoxyaniline serves as a key intermediate in the synthesis of biologically active compounds, particularly in the development of CNS-targeting pharmaceuticals due to its ability to enhance blood-brain barrier penetration. It is widely utilized in Suzuki-Miyaura coupling reactions to create fluorinated biphenyl scaffolds for kinase inhibitors. The compound’s electron-rich aniline core also makes it valuable in dye synthesis and as a ligand precursor in catalytic systems.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (66.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (66.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H412 (33.3%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (66.7%)
• Skin Irrit. 2 (66.7%)
• Eye Irrit. 2A (66.7%)
• Acute Tox. 4 (66.7%)
• STOT SE 3 (66.7%)
• Aquatic Chronic 3 (33.3%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.