Description

Nicotinamide Riboside Chloride (NRC) is a high-purity, bioactive form of vitamin B3, specifically a pyridinium derivative of nicotinamide with a ribose moiety. Its molecular formula, C₁₁H₁₅ClN₂O₅, reflects its unique structure as a chloride salt of nicotinamide riboside, a precursor to nicotinamide adenine dinucleotide (NAD⁺). This compound is widely recognized for its role in cellular energy metabolism, sirtuin activation, and potential anti-aging applications. With CAS number 23111-00-4, it is rigorously tested for identity, purity (≥98% by HPLC), and stability, ensuring reliability for research and pharmaceutical use. Available in lyophilized powder form, it is soluble in water and compatible with cell culture and biochemical assays. Ideal for studying NAD⁺-dependent pathways, mitochondrial function, and metabolic disorders.

Properties

• CAS Number: 23111-00-4
• Complexity: 314
• IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyridin-1-ium-3-carboxamide;chloride
• InChI: InChI=1S/C11H14N2O5.ClH/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11;/h1-4,7-9,11,14-16H,5H2,(H-,12,17);1H/t7-,8-,9-,11-;/m1./s1
• InChI Key: YABIFCKURFRPPO-IVOJBTPCSA-N
• Exact Mass: 290.0669493
• Molecular Formula: C11H15ClN2O5
• Molecular Weight: 290.70
• SMILES: C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N.[Cl-]
• Topological: 117
• Monoisotopic Mass: 290.0669493
• Synonyms: Pyridinium, 3-(aminocarbonyl)-1-beta-D-ribofuranosyl-, chloride (1:1), 807-820-5, 23111-00-4, Nicotinamide riboside chloride, 3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride, 8XM2XT8VWI, 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide;chloride, Nicotinamide riboside (chloride), MFCD27952781, Niagen; N-Ribosylnicotinamide Chloride; 3-Carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium Chloride, ss-Nicotinamide riboside, UNII-8XM2XT8VWI, SRT647;NIAGEN, Nicotinamide Riboside Chloride?, SCHEMBL17315043, CHEBI:229274, AKOS040758978, HY-123033A, Nicotinamide riboside chloride [WHO-DD], AC-29830, WS-00064, DB-210155, CS-0098615, F20757, F20758, EH-301 COMPONENT NICOTINAMIDE RIBOSIDE CHLORIDE, Pyridinium, 3-carbamoyl-1-beta-D-ribofuranosyl-, chloride, Pyridinium, 3-(aminocarbonyl)-1–D-ribofuranosyl-, chloride (1:1), Pyridinium, 3-(aminocarbonyl)-1-beta-D-ribofuranosyl-, chloride, PYRIDINIUM, 3-CARBAMOYL-1-.BETA.-D-RIBOFURANOSYL-, CHLORIDE, PYRIDINIUM, 3-(AMINOCARBONYL)-1-.BETA.-D-RIBOFURANOSYL-, CHLORIDE, 3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-iumchloride, 3-Carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridinium chloride

Nicotinamide Riboside Chloride is extensively used in aging research due to its NAD⁺-boosting properties, which support sirtuin-mediated cellular repair. It serves as a key substrate in metabolic studies investigating mitochondrial dysfunction and neurodegenerative diseases. Researchers also employ it in nutraceutical development for its potential to enhance longevity and metabolic health.

Safety and Hazards

GHS Hazard Statements

• Not Classified
• Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.

Hazard Classes and Categories

• Not Classified

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.