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Atomfair 2-Chloro-4-nitropyridine C5H3ClN2O2 CAS 23056-36-2

2-Chloro-4-nitropyridine (CAS: 23056-36-2) is a high-purity heterocyclic compound with the molecular formula C5H3ClN2O2. This versatile nitro-substituted pyridine derivative is widely utilized in organic synthesis, pharmaceutical research, and agrochemical development. The compound features a reactive chloro group at the 2-position and an electron-withdrawing nitro group at the 4-position, making it an excellent intermediate for nucleophilic substitution reactions and cross-coupling methodologies. Our product is supplied as a crystalline solid with ≥97% purity (HPLC), rigorously tested for consistency and stability. Ideal for medicinal chemistry applications, 2-Chloro-4-nitropyridine serves as a key building block in the synthesis of biologically active molecules, including kinase inhibitors and…

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Description

2-Chloro-4-nitropyridine (CAS: 23056-36-2) is a high-purity heterocyclic compound with the molecular formula C5H3ClN2O2. This versatile nitro-substituted pyridine derivative is widely utilized in organic synthesis, pharmaceutical research, and agrochemical development. The compound features a reactive chloro group at the 2-position and an electron-withdrawing nitro group at the 4-position, making it an excellent intermediate for nucleophilic substitution reactions and cross-coupling methodologies.

Our product is supplied as a crystalline solid with ≥97% purity (HPLC), rigorously tested for consistency and stability. Ideal for medicinal chemistry applications, 2-Chloro-4-nitropyridine serves as a key building block in the synthesis of biologically active molecules, including kinase inhibitors and antimicrobial agents. The compound is packaged under inert atmosphere to ensure long-term shelf stability and shipped with comprehensive analytical data (MSDS, NMR, HPLC).

Key Applications:
– Nucleophilic aromatic substitution reactions
– Suzuki-Miyaura cross-coupling precursor
– Pharmaceutical intermediate (API synthesis)
– Agrochemical research
– Material science applications

Properties

  • CAS Number: 23056-36-2
  • Complexity: 136
  • IUPAC Name: 2-chloro-4-nitro-pyridine
  • InChI: InChI=1S/C5H3ClN2O2/c6-5-3-4(8(9)10)1-2-7-5/h1-3H
  • InChI Key: LIEPVGBDUYKPLC-UHFFFAOYSA-N
  • Exact Mass: 157.9883050
  • Molecular Formula: C5H3ClN2O2
  • Molecular Weight: 158.54
  • SMILES: C1=CN=C(C=C1[N+](=O)[O-])Cl
  • Topological: 58.7
  • Monoisotopic Mass: 157.9883050
  • Synonyms: 2-Chloro-4-nitropyridine, 23056-36-2, DTXSID50352743, DTXCID20303808, 627-980-8, Pyridine, 2-chloro-4-nitro-, MFCD00661454, 2-chloro-4-nitro-pyridine, 2-chloro-4nitropyridine, 2chloro-4-nitropyridine, 2-chloro-4-(nitro)pyridine, SCHEMBL190411, SCHEMBL4927400, SCHEMBL4927715, 2-Chloro-4-nitropyridine, 97%, BCP26367, BBL100163, SBB016178, STL227623, AKOS000267446, AKOS000320214, AC-5933, CS-W010890, HY-W010174, PB32222, PS-5234, BP-12616, SY005657, DB-005222, C2283, ST45174490, EN300-56137, AJ-333/25006257, F1921-0024

2-Chloro-4-nitropyridine is primarily employed as a synthetic intermediate in pharmaceutical research, particularly for constructing pyridine-based drug scaffolds. The compound’s dual functionality enables sequential modification through nucleophilic displacement of chlorine followed by reduction of the nitro group. It finds specific use in developing kinase inhibitors and antimicrobial agents. In material science, it serves as a precursor for functionalized pyridine ligands in coordination chemistry.

Safety and Hazards

GHS Hazard Statements

  • H302 (97.9%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H312 (89.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]
  • H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (97.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H332 (89.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]
  • H335 (95.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (97.9%)
  • Acute Tox. 4 (89.6%)
  • Skin Irrit. 2 (97.9%)
  • Eye Irrit. 2 (97.9%)
  • Acute Tox. 4 (89.6%)
  • STOT SE 3 (95.8%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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