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Atomfair 3-Oxotetrahydrofuran C4H6O2 CAS 22929-52-8

3-Oxotetrahydrofuran (CAS: 22929-52-8) is a high-purity cyclic ketone with the molecular formula C4H6O2, widely utilized in organic synthesis and pharmaceutical research. This versatile intermediate features a tetrahydrofuran backbone with a ketone group at the 3-position, enabling its use in the preparation of heterocyclic compounds, chiral auxiliaries, and bioactive molecules. Its stability and reactivity make it ideal for Grignard reactions, reductions, and nucleophilic additions. Supplied as a clear to pale-yellow liquid with ≥95% purity (GC), it is rigorously tested for consistency and stored under nitrogen to prevent degradation. Compatible with anhydrous conditions, this compound is essential for laboratories focused on fine…

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Description

3-Oxotetrahydrofuran (CAS: 22929-52-8) is a high-purity cyclic ketone with the molecular formula C4H6O2, widely utilized in organic synthesis and pharmaceutical research. This versatile intermediate features a tetrahydrofuran backbone with a ketone group at the 3-position, enabling its use in the preparation of heterocyclic compounds, chiral auxiliaries, and bioactive molecules. Its stability and reactivity make it ideal for Grignard reactions, reductions, and nucleophilic additions. Supplied as a clear to pale-yellow liquid with ≥95% purity (GC), it is rigorously tested for consistency and stored under nitrogen to prevent degradation. Compatible with anhydrous conditions, this compound is essential for laboratories focused on fine chemicals, medicinal chemistry, and material science applications.

Properties

  • CAS Number: 22929-52-8
  • Complexity: 67.9
  • IUPAC Name: tetrahydrofuran-3-one
  • InChI: InChI=1S/C4H6O2/c5-4-1-2-6-3-4/h1-3H2
  • InChI Key: JLPJFSCQKHRSQR-UHFFFAOYSA-N
  • Exact Mass: 86.036779430
  • Molecular Formula: C4H6O2
  • Molecular Weight: 86.09
  • SMILES: C1COCC1=O
  • Topological: 26.3
  • Monoisotopic Mass: 86.036779430
  • Physical Description: Solid
  • Synonyms: 22929-52-8, 3-Oxotetrahydrofuran, Dihydrofuran-3(2H)-one, DTXSID80336157, DTXCID30287246, 805-925-0, Oxolan-3-one, Dihydro-3(2H)-furanone, 3(2H)-Furanone, dihydro-, TETRAHYDROFURAN-3-ONE, dihydrofuran-3-one, Dihydro-furan-3-one, MFCD07778393, 3(2H)-Furanone, dihydro, 4,5-dihydro-3(2h)-furanone, oxotetrahydrofuran, 4,5-Dihydro-3(2H)-furanone; Dihydro-3(2H)-furanone; Dihydrofuran-3-one; Oxolan-3-one, 3-ketotetrahydrofuran, tetrahydrofuran-3 -one, dihydrofuran-3 (2H)-one, dihydrofuran-3(2 H)-one, SCHEMBL44273, SCHEMBL293764, SCHEMBL293998, SCHEMBL294044, SCHEMBL20183604, CHEBI:166530, BCP14176, CS-D1574, BBL103228, STL557038, AKOS006282737, PB17440, PS-9364, HY-33900, SY003100, DB-006516, T2971, EN300-70361

3-Oxotetrahydrofuran serves as a key intermediate in synthesizing pharmaceuticals, agrochemicals, and fragrances. Its carbonyl reactivity facilitates the construction of complex heterocycles, while its tetrahydrofuran scaffold is valuable in polymer chemistry. Researchers employ it in asymmetric catalysis and as a precursor for gamma-butyrolactone derivatives. Suitable for solvent-free reactions and kinetic studies.

Safety and Hazards

GHS Hazard Statements

  • H225 (20%): Highly Flammable liquid and vapor [Danger Flammable liquids]
  • H226 (50%): Flammable liquid and vapor [Warning Flammable liquids]
  • H302 (60%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (70%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

  • Flam. Liq. 2 (20%)
  • Flam. Liq. 3 (50%)
  • Acute Tox. 4 (60%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (70%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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