Description

2-Bromo-4-chloropyridine (CAS No. 22918-01-0) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₃BrClN. This heteroaromatic compound is a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring both bromine and chlorine substituents on the pyridine ring, enables selective functionalization via cross-coupling reactions (e.g., Suzuki, Stille) or nucleophilic substitutions. Available in >98% purity (GC), this crystalline solid is packaged under inert conditions to ensure stability. Ideal for synthesizing active pharmaceutical ingredients (APIs), ligands, and functional materials. MSDS and analytical certificates (HPLC, NMR) available upon request.

Properties

• CAS Number: 22918-01-0
• Complexity: 78.8
• IUPAC Name: 2-bromo-4-chloro-pyridine
• InChI: InChI=1S/C5H3BrClN/c6-5-3-4(7)1-2-8-5/h1-3H
• InChI Key: SURKZMFXICWLHU-UHFFFAOYSA-N
• Exact Mass: 190.91374
• Molecular Formula: C5H3BrClN
• Molecular Weight: 192.44
• SMILES: C1=CN=C(C=C1Cl)Br
• Topological: 12.9
• Monoisotopic Mass: 190.91374
• Synonyms: 2-Bromo-4-chloropyridine, 22918-01-0, DTXSID80376497, DTXCID80327525, 685-965-1, Pyridine, 2-bromo-4-chloro-, MFCD03840757, 2-bromo-4-chloro-pyridine, 2-bromo-4-chloro pyridine, 2-bromo-4 chloropyridine, 4-Chloro-2-bromopyridine, SCHEMBL135549, SCHEMBL4926730, SCHEMBL4928151, SCHEMBL7759071, 2-Bromo-4-chloropyridine, 95%, SURKZMFXICWLHU-UHFFFAOYSA-N, SBB054398, AKOS005145598, AC-1038, CS-W003129, FB08159, GS-6663, HY-W003129, PB23373, SY017821, DB-025285, B4407, EN300-86428

Application

2-Bromo-4-chloropyridine serves as a key intermediate in the synthesis of biologically active compounds, including kinase inhibitors and antimicrobial agents. Its halogenated pyridine core facilitates palladium-catalyzed cross-coupling reactions to construct complex heterocycles. Researchers utilize this compound in medicinal chemistry for structure-activity relationship (SAR) studies due to its orthogonal reactivity sites. Also employed in material science for developing functionalized ligands in catalysis.

Safety and Hazards

GHS Hazard Statements

• H302 (97.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (89.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (10.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.9%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (89.4%)
• Eye Irrit. 2 (10.6%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.