Description

(2-Bromo-4-fluorophenyl)methanol (CAS No. 229027-89-8) is a high-purity aromatic alcohol derivative featuring both bromo and fluoro substituents on the phenyl ring. This compound, with the molecular formula C₇H₆BrFO, is a versatile building block in organic synthesis and pharmaceutical research. Its unique structure makes it valuable for the development of novel bioactive molecules, ligands, and functional materials. The product is supplied as a crystalline solid or neat liquid (depending on storage conditions) with ≥95% purity (GC), ensuring consistency for sensitive applications. Proper handling under inert atmosphere is recommended due to potential sensitivity to oxidation. Available in research quantities (100mg to 10kg) with optional custom packaging.

Key Specifications:
– Molecular Weight: 205.03 g/mol
– Melting Point: Data available upon request
– Storage: 2-8°C under nitrogen
– Hazard Codes: Xi (Irritant)

Properties

• CAS Number: 229027-89-8
• Complexity: 110
• IUPAC Name: (2-bromo-4-fluoro-phenyl)methanol
• InChI: InChI=1S/C7H6BrFO/c8-7-3-6(9)2-1-5(7)4-10/h1-3,10H,4H2
• InChI Key: XGAMLBPEVCLQEJ-UHFFFAOYSA-N
• Exact Mass: 203.95861
• Molecular Formula: C7H6BrFO
• Molecular Weight: 205.02
• SMILES: C1=CC(=C(C=C1F)Br)CO
• Topological: 20.2
• Monoisotopic Mass: 203.95861
• Synonyms: (2-bromo-4-fluorophenyl)methanol, 679-560-9, 2-Bromo-4-fluorobenzyl Alcohol, 229027-89-8, Benzenemethanol, 2-bromo-4-fluoro-, MFCD00672925, 2-BROMO-4-FLUOROBENZYLALCOHOL, (2-bromo-4-fluorophenyl)methan-1-ol, SCHEMBL901450, 2-bromo-4-flourobenzyl alcohol, SCHEMBL15351654, DTXSID80378395, XGAMLBPEVCLQEJ-UHFFFAOYSA-N, (2-bromo-4-fluoro-phenyl)methanol, SBB063434, AKOS009158513, AB06857, CS-W002661, PS-8125, SY018199, B3417, EN300-52960, Z397587428

Application

(2-Bromo-4-fluorophenyl)methanol serves as a key intermediate in Suzuki-Miyaura cross-coupling reactions for biaryl synthesis. The compound finds application in medicinal chemistry as a precursor for fluorinated drug candidates targeting CNS disorders. Researchers utilize its reactive benzylic alcohol group for etherification or esterification in material science applications. The orthogonal reactivity of bromo and fluoro substituents enables sequential functionalization in complex molecule construction.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (50%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.