Description

3-Chloro-2-hydrazinylpyridine (CAS No. 22841-92-5) is a high-purity chemical compound with the molecular formula C₅H₆ClN₃, designed for advanced research and pharmaceutical applications. This heterocyclic hydrazine derivative features a chloro-substituted pyridine ring, making it a versatile intermediate for organic synthesis, medicinal chemistry, and agrochemical development. With a molecular weight of 143.57 g/mol, it is supplied as a crystalline solid with guaranteed ≥95% purity (HPLC) to ensure consistency in experimental results. Ideal for nucleophilic substitution reactions, cyclizations, and the synthesis of biologically active molecules, this compound is meticulously packaged under inert conditions to maintain stability. Available in quantities ranging from milligrams to kilograms, it is suitable for both laboratory-scale investigations and industrial-scale production. Store in a cool, dry place away from light and moisture to preserve its reactivity and shelf life.

Properties

• CAS Number: 22841-92-5
• Complexity: 88.3
• IUPAC Name: (3-chloro-2-pyridyl)hydrazine
• InChI: InChI=1S/C5H6ClN3/c6-4-2-1-3-8-5(4)9-7/h1-3H,7H2,(H,8,9)
• InChI Key: XAYCTBDPZIKHCW-UHFFFAOYSA-N
• Exact Mass: 143.0250249
• Molecular Formula: C5H6ClN3
• Molecular Weight: 143.57
• SMILES: C1=CC(=C(N=C1)NN)Cl
• Topological: 50.9
• Monoisotopic Mass: 143.0250249
• Synonyms: 22841-92-5, 3-Chloro-2-hydrazinylpyridine, (3-CHLORO-PYRIDIN-2-YL)-HYDRAZINE, (3-Chloropyridin-2-yl)hydrazine, DTXSID20945540, DTXCID801373854, 474-260-2, 690-673-2, 3-Chloro-2-hydrazinopyridine, 1-(3-chloropyridin-2-yl)hydrazine, MFCD01936479, 3-chloro-2(1H)-pyridinone hydrazone, 3-Chloro-2-hydrazylpyridine, 2-hydrazino-3-chloropyridine, 2(1H)-Pyridinone, 3-chloro-, hydrazone, 3-chloro-2-pyridylhydrazine, 2-Hydrazinyl-3-chloropyridine, 3-chloropyridin-2-ylhydrazine, SCHEMBL385136, 3-Chloro-2-hydrazinopyridine #, 3-chloro-2-pyridin-2-ylhydrazine, BCP15445, SBB068633, AKOS000133653, AKOS028109413, CS-W002868, SB75557, 3-chloro-2-hydrazinopyridine, AldrichCPR, SY011483, DB-017426, NS00077864, EN300-44833, 8B-018

3-Chloro-2-hydrazinylpyridine serves as a key building block in the synthesis of heterocyclic compounds, particularly in the development of pharmaceuticals and agrochemicals. Researchers utilize it to create pyrazole and triazole derivatives via cyclocondensation reactions, which are prevalent in drug discovery. Its reactive hydrazine group enables conjugation with carbonyl compounds, facilitating the production of hydrazones for catalytic or material science applications. In medicinal chemistry, it is employed to design potent inhibitors targeting enzymes or receptors. Handle with standard laboratory precautions due to its potential sensitivity to oxidation and moisture.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H334 (50%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P233, P260, P261, P264, P264+P265, P270, P271, P280, P284, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (50%)
• Resp. Sens. 1 (50%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.