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Atomfair 1,3-Difluoro-5-nitrobenzene C6H3F2NO2 CAS 2265-94-3

1,3-Difluoro-5-nitrobenzene (CAS No. 2265-94-3) is a high-purity aromatic compound with the molecular formula C6H3F2NO2. This fluorinated nitrobenzene derivative is a valuable intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and advanced materials. Its unique structure, featuring two fluorine atoms and a nitro group in a meta-substituted benzene ring, enables selective reactivity in nucleophilic aromatic substitution (SNAr) reactions. The compound is supplied as a crystalline solid with ≥98% purity (GC), ensuring consistency for research and industrial applications. Store in a cool, dry place away from light and oxidizing agents. Suitable for use in cross-coupling reactions, heterocycle synthesis, and…

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Description

1,3-Difluoro-5-nitrobenzene (CAS No. 2265-94-3) is a high-purity aromatic compound with the molecular formula C6H3F2NO2. This fluorinated nitrobenzene derivative is a valuable intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and advanced materials. Its unique structure, featuring two fluorine atoms and a nitro group in a meta-substituted benzene ring, enables selective reactivity in nucleophilic aromatic substitution (SNAr) reactions. The compound is supplied as a crystalline solid with ≥98% purity (GC), ensuring consistency for research and industrial applications. Store in a cool, dry place away from light and oxidizing agents. Suitable for use in cross-coupling reactions, heterocycle synthesis, and as a building block for liquid crystals or electronic materials.

Properties

  • CAS Number: 2265-94-3
  • Complexity: 149
  • IUPAC Name: 1,3-difluoro-5-nitro-benzene
  • InChI: InChI=1S/C6H3F2NO2/c7-4-1-5(8)3-6(2-4)9(10)11/h1-3H
  • InChI Key: AUQBBDWDLJSKMI-UHFFFAOYSA-N
  • Exact Mass: 159.01318466
  • Molecular Formula: C6H3F2NO2
  • Molecular Weight: 159.09
  • SMILES: C1=C(C=C(C=C1F)F)[N+](=O)[O-]
  • Topological: 45.8
  • Monoisotopic Mass: 159.01318466
  • Synonyms: 3,5-Difluoronitrobenzene, 1,3-Difluoro-5-nitrobenzene, 2265-94-3, EINECS 218-867-0, NSC-10260, 27ZN24954J, AUQBBDWDLJSKMI-UHFFFAOYSA-, DTXSID30177193, NSC 10260, DTXCID7099684, 218-867-0, auqbbdwdljskmi-uhfffaoysa-n, inchi=1/c6h3f2no2/c7-4-1-5(8)3-6(2-4)9(10)11/h1-3h, Benzene, 1,3-difluoro-5-nitro-, 1,3-difluoro-5-nitro-benzene, 3,5-difluoro-1-nitrobenzene, MFCD00012142, 1-nitro-3,5-difluorobenzene, 2,6-difluoro-4-nitrobenzene, NSC10260, 3,5-difluoro-nitrobenzene, SCHEMBL146142, SCHEMBL1172437, SCHEMBL2351240, UNII-27ZN24954J, 1,3-Difluoro-5-nitrobenzene #, 3,5-Difluoronitrobenzene, 99%, SBB063103, AKOS005063583, AC-2665, CS-W016187, AS-33088, BP-13437, D3426, NS00049134, ST51038157, EN300-50140, Z600389896

Application

1,3-Difluoro-5-nitrobenzene serves as a versatile precursor in medicinal chemistry for creating fluorinated drug candidates, particularly kinase inhibitors and antimicrobial agents. In material science, it’s employed to synthesize liquid crystal compounds and electron-deficient aromatic systems for organic semiconductors. The nitro group facilitates further functionalization via reduction to amines or conversion to other valuable intermediates.

Safety and Hazards

GHS Hazard Statements

  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2 (100%)
  • STOT SE 3 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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