Description

2,4-Difluoro-1-iodobenzene (CAS No. 2265-93-2) is a high-purity halogenated aromatic compound with the molecular formula C₆H₃F₂I. This versatile intermediate is widely used in organic synthesis, particularly in pharmaceutical and agrochemical research. The compound features two fluorine substituents at the 2- and 4-positions and an iodine atom at the 1-position of the benzene ring, making it a valuable building block for cross-coupling reactions such as Suzuki-Miyaura and Stille couplings. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed, light-resistant packaging to maintain stability. Ideal for researchers developing novel fluorinated compounds or investigating structure-activity relationships.

Properties

• CAS Number: 2265-93-2
• Complexity: 97.1
• IUPAC Name: 2,4-difluoro-1-iodo-benzene
• InChI: InChI=1S/C6H3F2I/c7-4-1-2-6(9)5(8)3-4/h1-3H
• InChI Key: YKLDMAPEGQYZRT-UHFFFAOYSA-N
• Exact Mass: 239.92475
• Molecular Formula: C6H3F2I
• Molecular Weight: 239.99
• SMILES: C1=CC(=C(C=C1F)F)I
• Monoisotopic Mass: 239.92475
• Synonyms: 2,4-Difluoro-1-iodobenzene, 629-507-0, 2,4-Difluoroiodobenzene, 2265-93-2, 1,3-Difluoro-4-iodobenzene, MFCD00040151, 2,4-Difluoro-1-iodobenze, Benzene, 2,4-difluoro-1-iodo-, 2,4-difluoro-1-iodo-benzene, NSC68264, 2,4-difluoro-iodobenzene, SCHEMBL79432, SCHEMBL26968215, DTXSID70177192, NSC 68264, NSC-68264, SBB099182, AKOS005254541, AC-7207, CS-W010293, GS-6052, MB00398, SY005121, DB-030790, D2545, EN300-197626, Z381540726

Application

2,4-Difluoro-1-iodobenzene serves as a key precursor in the synthesis of fluorinated pharmaceuticals, liquid crystals, and advanced materials. Its reactivity in palladium-catalyzed cross-coupling reactions enables the construction of complex biaryl structures. The compound is particularly valuable in medicinal chemistry for introducing fluorine motifs to enhance metabolic stability and bioavailability. Researchers also utilize it to develop PET radiotracers and agrochemicals.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.9%)

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