Description

1,4-Difluoro-2-iodobenzene (CAS No. 2265-92-1) is a high-purity halogenated aromatic compound with the molecular formula C₆H₃F₂I. This versatile intermediate is widely used in organic synthesis, pharmaceutical research, and material science due to its reactive iodine and fluorine substituents. Its unique structure enables efficient cross-coupling reactions, such as Suzuki-Miyaura and Sonogashira couplings, making it invaluable for constructing complex molecules. Available in >97% purity, this compound is rigorously tested for consistency and stability, ensuring reliable performance in demanding applications. Packaged under inert gas to prevent degradation, it is ideal for researchers requiring precise fluorinated building blocks.

Properties

• CAS Number: 2265-92-1
• Complexity: 97.1
• IUPAC Name: 1,4-difluoro-2-iodo-benzene
• InChI: InChI=1S/C6H3F2I/c7-4-1-2-5(8)6(9)3-4/h1-3H
• InChI Key: WBYVNDUCUMNZPM-UHFFFAOYSA-N
• Exact Mass: 239.92475
• Molecular Formula: C6H3F2I
• Molecular Weight: 239.99
• SMILES: C1=CC(=C(C=C1F)I)F
• Monoisotopic Mass: 239.92475
• Synonyms: 1,4-Difluoro-2-iodobenzene, DTXSID70278835, DTXCID00229991, 639-297-2, 2265-92-1, 2,5-Difluoroiodobenzene, MFCD03094151, 2,5-Difluoro-1-iodobenzene, Benzene, 1,4-difluoro-2-iodo-, NSC10262, SCHEMBL959207, 1,4-difluoro-2-iodo-benzene, 2,5-Difluoroiodobenzene, 97%, SCHEMBL16414619, CK2343, NSC-10262, SBB099181, AKOS009158999, DS-7413, SY050477, DB-020078, CS-0157075, D3594, EN300-103733

1,4-Difluoro-2-iodobenzene serves as a key precursor in the synthesis of fluorinated pharmaceuticals, agrochemicals, and liquid crystals. Its iodine moiety facilitates palladium-catalyzed coupling reactions to form biaryl structures. The compound is also used in the development of PET radiotracers and OLED materials. Handle under nitrogen/argon due to sensitivity to light and moisture.

Safety and Hazards

GHS Hazard Statements

• H302+H312+H332 (12.5%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (12.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (87.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (87.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (25%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (12.5%)
• Skin Irrit. 2 (87.5%)
• Eye Irrit. 2A (87.5%)
• STOT SE 3 (25%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.