Description

2,3-Dichloro-5-nitropyridine (CAS No. 22353-40-8) is a high-purity heterocyclic compound with the molecular formula C₅H₂Cl₂N₂O₂. This nitro-substituted pyridine derivative is a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its distinct structure, featuring two chlorine atoms and a nitro group on the pyridine ring, enables selective functionalization for the development of complex molecules. Available in >98% purity (HPLC), this compound is rigorously tested for consistency and stability. Suitable for use in cross-coupling reactions, nucleophilic substitutions, and as a precursor for bioactive compounds. Packaged under inert gas to ensure longevity and shipped with comprehensive analytical data (GC/MS, NMR).

Properties

• CAS Number: 22353-40-8
• Complexity: 161
• IUPAC Name: 2,3-dichloro-5-nitro-pyridine
• InChI: InChI=1S/C5H2Cl2N2O2/c6-4-1-3(9(10)11)2-8-5(4)7/h1-2H
• InChI Key: XLPDVAVQKGDHNO-UHFFFAOYSA-N
• Exact Mass: 191.9493327
• Molecular Formula: C5H2Cl2N2O2
• Molecular Weight: 192.98
• SMILES: C1=C(C=NC(=C1Cl)Cl)[N+](=O)[O-]
• Topological: 58.7
• Monoisotopic Mass: 191.9493327
• Synonyms: 2,3-Dichloro-5-nitropyridine, 22353-40-8, Pyridine, 2,3-dichloro-5-nitro-, DTXSID90376741, DTXCID00327769, 683-696-4, xlpdvavqkgdhno-uhfffaoysa-n, MFCD03840432, 2,3-dichloro-5-nitro-pyridine, 2,3-Dichloro-5-nitropyridine, 97%, dichloro-5-nitro pyridine, 2,3dichloro-5-nitropyridine, SCHEMBL364459, 2,3-dichloro-5 nitro pyridine, 2,3-dichloro-5-nitro pyridine, SCHEMBL18820156, BCP13919, SBB065354, AKOS005072644, AC-1151, CS-W003123, FC-0614, FD32624, SY019256, DB-003872, D4416, EN300-81008

Application

2,3-Dichloro-5-nitropyridine serves as a key intermediate in the synthesis of pharmaceuticals, including potential kinase inhibitors and antimicrobial agents. Its reactive sites facilitate Suzuki-Miyaura and Buchwald-Hartwig couplings for drug discovery. In material science, it contributes to the development of liquid crystals and OLED precursors. The nitro group also allows reduction to amino derivatives for further functionalization.

Safety and Hazards

GHS Hazard Statements

• H301 (97.6%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (97.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (97.6%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (97.6%)
• STOT SE 3 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.