Description

6-Methyl-5-nitropyridin-2-amine (CAS No. 22280-62-2) is a high-purity nitropyridine derivative with the molecular formula C₆H₇N₃O₂. This fine chemical is extensively utilized in pharmaceutical research, agrochemical development, and organic synthesis due to its versatile reactivity as a building block. The compound features a nitro group at the 5-position and an amino group at the 2-position of the pyridine ring, making it ideal for nucleophilic substitution and reduction reactions. Available in ≥98% purity (HPLC), it is supplied as a yellow to orange crystalline powder with strict quality control to ensure consistency for sensitive applications. Suitable for use in GMP/GLP environments, it is packaged under inert gas to prevent degradation. Store in a cool, dry place away from light and oxidizing agents.

Properties

• CAS Number: 22280-62-2
• Complexity: 156
• IUPAC Name: 6-methyl-5-nitro-pyridin-2-amine
• InChI: InChI=1S/C6H7N3O2/c1-4-5(9(10)11)2-3-6(7)8-4/h2-3H,1H3,(H2,7,8)
• InChI Key: BGMZTBKXOFFTBJ-UHFFFAOYSA-N
• Exact Mass: 153.053826475
• Molecular Formula: C6H7N3O2
• Molecular Weight: 153.14
• SMILES: CC1=C(C=CC(=N1)N)[N+](=O)[O-]
• Topological: 84.7
• Monoisotopic Mass: 153.053826475
• Synonyms: 6-methyl-5-nitropyridin-2-amine, 675-118-4, 22280-62-2, 2-Amino-6-methyl-5-nitropyridine, 6-Amino-3-nitro-2-picoline, 2-amino-5-nitro-6-methylpyridine, 6-amino-3-nitro-2-methylpyridine, 6-amino-2-methyl-3-nitropyridine, 2-amino-5-nitro-6-picoline, MFCD00053582, 2-Amino-5-Nitro-6-Methyl pyridine, 6-methyl-5-nitro-2-pyridylamine, 6-Methyl-5-nitro-2-pyridinamine, 2-Pyridinamine, 6-methyl-5-nitro-, NSC63855, 6-methyl-5-nitro-pyridin-2-ylamine, NCIOpen2_000133, SCHEMBL539616, DTXSID00289772, 6-Methyl-5-nitropyridin-2-ylamine, BCP23376, 2-Methyl-3-nitro-6-amino pyridine, 6-Methyl-5-nitro-2-pyridinamine #, NSC 63855, NSC-63855, SBB004047, AKOS002676259, AB02246, AC-5416, CS-W002262, PS-4395, BP-10019, SY016216, DB-031374, A2326, ST50949486, EN300-85402, AN-228/40262599, Z1203162411, 2-Amino-5-nitro-6-picoline (2-Amino-6-methyl-5-nitropyridine)

6-Methyl-5-nitropyridin-2-amine serves as a key intermediate in the synthesis of pharmaceuticals, particularly for antimalarial and antiviral agents. Its nitro and amino functional groups enable facile derivatization for heterocyclic chemistry applications. Researchers also employ it in ligand design for catalytic systems and as a precursor for dyes and pigments. In agrochemicals, it contributes to the development of novel pesticides.

Safety and Hazards

GHS Hazard Statements

• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (33.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (33.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (33.3%)
• Acute Tox. 4 (33.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (33.3%)
• STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.