Description

2-Chloro-3-methyl-5-nitropyridine (CAS No. 22280-56-4) is a high-purity nitropyridine derivative with the molecular formula C₆H₅ClN₂O₂. This compound is a versatile intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialty chemicals. Its unique structure, featuring a chloro, methyl, and nitro substituent on the pyridine ring, makes it a valuable building block for heterocyclic chemistry. Our product is rigorously tested for purity and consistency, ensuring optimal performance in research and industrial applications. Available in various quantities, it is supplied with comprehensive analytical data including HPLC, NMR, and MS for quality assurance.

Properties

• CAS Number: 22280-56-4
• Complexity: 159
• IUPAC Name: 2-chloro-3-methyl-5-nitro-pyridine
• InChI: InChI=1S/C6H5ClN2O2/c1-4-2-5(9(10)11)3-8-6(4)7/h2-3H,1H3
• InChI Key: OSIOIGXJUZTWRI-UHFFFAOYSA-N
• Exact Mass: 172.0039551
• Molecular Formula: C6H5ClN2O2
• Molecular Weight: 172.57
• SMILES: CC1=CC(=CN=C1Cl)[N+](=O)[O-]
• Topological: 58.7
• Monoisotopic Mass: 172.0039551
• Synonyms: 2-Chloro-3-methyl-5-nitropyridine, 22280-56-4, 2-Chloro-5-nitro-3-picoline, 2-chloro-5-nitro-3-methylpyridine, 45ZN7UCB3M, EINECS 244-889-5, NSC-63887, OSIOIGXJUZTWRI-UHFFFAOYSA-, DTXSID70176827, NSC 63887, DTXCID0099318, 244-889-5, inchi=1/c6h5cln2o2/c1-4-2-5(9(10)11)3-8-6(4)7/h2-3h,1h3, MFCD00173686, Pyridine, 2-chloro-3-methyl-5-nitro-, 2-chloro-3-methyl-5-nitro-pyridine, NSC63887, 2-Chloro-3-methyl-5-Nitro pyridine, UNII-45ZN7UCB3M, SCHEMBL801244, 2-Chloro-3-methyl-5nitropyridine, 2-Chloro-5-nitro-3-picoline (2-Chloro-3-methyl-5-nitropyridine), BCP22226, CS-D0963, BBL101878, SBB003831, STL555675, 2-chloro-3-methyl -5-nitro-pyridine, AKOS005064142, PB25986, PS-4180, SB20915, AC-10878, HY-32796, SY004411, 2-Chloro-3-methyl-5-nitropyridine, 97%, DB-025117, A4785, C2020, NS00027118, EN300-63950, Z991524294

Application

2-Chloro-3-methyl-5-nitropyridine is widely used as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. Its reactive nitro and chloro groups facilitate further functionalization, making it valuable for constructing complex heterocyclic frameworks. Researchers also employ it in the development of dyes, ligands, and catalysts due to its electron-deficient pyridine core. This compound is particularly useful in cross-coupling reactions and nucleophilic substitution processes.

Safety and Hazards

GHS Hazard Statements

• H301 (87.2%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (83%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (14.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (87.2%)
• Skin Irrit. 2 (97.9%)
• Eye Dam. 1 (83%)
• Eye Irrit. 2 (14.9%)
• STOT SE 3 (95.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.