Description

3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)- (CAS No. 222631-44-9), also known as Galidesivir Hydrochloride or BCX 4430 Hydrochloride, is a high-purity synthetic nucleoside analogue with a molecular formula of C₁₁H₁₆ClN₅O₃. This compound is a hydrochloride salt form of Galidesivir, exhibiting potent antiviral activity against a broad spectrum of RNA viruses, including filoviruses and flaviviruses. Its stereospecific structure ((2S,3S,4R,5R)-configuration) ensures optimal binding to viral polymerases, making it a valuable tool for antiviral research. Ideal for pharmaceutical development and biochemical studies, this product is rigorously tested for purity (>98% by HPLC) and stability, supplied as a lyophilized powder or in solution for ease of use. Store at -20°C under inert conditions to maintain integrity.

Properties

• CAS Number: 222631-44-9
• Complexity: 333
• IUPAC Name: (2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol;hydrochloride
• InChI: InChI=1S/C11H15N5O3.ClH/c12-11-8-6(14-3-15-11)4(1-13-8)7-10(19)9(18)5(2-17)16-7;/h1,3,5,7,9-10,13,16-19H,2H2,(H2,12,14,15);1H/t5-,7+,9-,10+;/m1./s1
• InChI Key: PCCHVYNGFMEGIG-QPAIBFMUSA-N
• Exact Mass: 301.0941671
• Molecular Formula: C11H16ClN5O3
• Molecular Weight: 301.73
• SMILES: C1=C(C2=C(N1)C(=NC=N2)N)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O.Cl
• Topological: 140
• Monoisotopic Mass: 301.0941671
• Synonyms: 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-, 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-, 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo(3,2-d)pyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-, 222631-44-9, Galidesivir hydrochloride, BCX 4430, BCX 4430 Hydrochloride, Galidesivir (hydrochloride), 1EL1K52SH1, (2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol;hydrochloride, Bcx-4430 hydrochloride, SCHEMBL4838048, PCCHVYNGFMEGIG-QPAIBFMUSA-N, DTXSID001028039, AKOS030526727, AT32549, CS-3778, NB58350, 2-(4-Amino-5H-pyrrolo(3,2-d)pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol, DA-61549, HY-18649, MS-24349, (2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol hydrochloride, (2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol;Galidesivir, 3,4-PYRROLIDINEDIOL, 2-(4-AMINO-5H-PYRROLO(3,2-D)PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-, HYDROCHLORIDE (1:1), (2S,3S,4R,5R)-

Galidesivir Hydrochloride is primarily used in antiviral research, particularly for studying RNA virus inhibition mechanisms. It has shown efficacy against Ebola, Marburg, and Zika viruses in preclinical models. The compound acts as a chain-terminating nucleotide analogue, disrupting viral replication. Researchers utilize it in in vitro and in vivo studies to explore therapeutic potential. Its hydrochloride form enhances solubility for experimental applications.

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