Description

4-Bromo-2-(trifluoromethoxy)benzaldehyde (CAS No. 220996-80-5) is a high-purity aromatic aldehyde compound featuring a bromo substituent at the 4-position and a trifluoromethoxy group at the 2-position of the benzaldehyde ring. With the molecular formula C₈H₄BrF₃O₂, this specialized chemical is designed for advanced synthetic applications in pharmaceutical, agrochemical, and materials science research. Its unique structure makes it a valuable building block for the synthesis of complex molecules, particularly in the development of fluorinated compounds. The product is rigorously tested for purity and stability, ensuring reliable performance in demanding laboratory conditions. Suitable for use in organic synthesis, cross-coupling reactions, and as a precursor for heterocyclic compounds, this reagent is packaged under inert conditions to maintain its integrity.

Properties

• CAS Number: 220996-80-5
• Complexity: 207
• IUPAC Name: 4-bromo-2-(trifluoromethoxy)benzaldehyde
• InChI: InChI=1S/C8H4BrF3O2/c9-6-2-1-5(4-13)7(3-6)14-8(10,11)12/h1-4H
• InChI Key: AXZVKHIUQLEMPJ-UHFFFAOYSA-N
• Exact Mass: 267.93468
• Molecular Formula: C8H4BrF3O2
• Molecular Weight: 269.01
• SMILES: C1=CC(=C(C=C1Br)OC(F)(F)F)C=O
• Topological: 26.3
• Monoisotopic Mass: 267.93468
• Synonyms: 4-Bromo-2-(trifluoromethoxy)benzaldehyde, 220996-80-5, DTXSID90595692, DTXCID20546455, 4-bromo-2-trifluoromethoxy-benzaldehyde, MFCD12406886, 4-Bromo-2-trifluoromethoxybenzaldehyde, Benzaldehyde, 4-bromo-2-(trifluoromethoxy)-, 4-bromo-2-(trifluoro-methoxy)benzaldehyde, 4-bromo-2-[(trifluoromethyl)oxy]benzaldehyde, SCHEMBL207935, AKOS005063512, CS-W022089, GS-3633, SB35512, SY030424, EN300-6508665, 4-Bromo-2-(trifluoromethoxy)benzaldehyde, AldrichCPR

Application

4-Bromo-2-(trifluoromethoxy)benzaldehyde serves as a versatile intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals. Its reactive aldehyde group enables facile conversion into alcohols, acids, or imines, while the bromo and trifluoromethoxy substituents facilitate further functionalization via cross-coupling reactions. Researchers utilize this compound in the development of bioactive molecules, particularly those targeting CNS disorders and inflammation. The trifluoromethoxy group enhances metabolic stability and lipophilicity, making it valuable in drug discovery.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.