Description

(3-((Tert-butoxy)carbonyl)phenyl)boronic acid (CAS No. 220210-56-0) is a high-purity boronic acid derivative with the molecular formula C₁₁H₁₅BO₄. This compound features a tert-butoxycarbonyl (Boc) protecting group, making it a valuable intermediate in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. Its IUPAC name is [3-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]boronic acid, and it is characterized by excellent stability and reactivity under controlled conditions. Ideal for pharmaceutical research, material science, and fine chemical synthesis, this product is rigorously tested for quality, ensuring ≥95% purity (HPLC). Available in crystalline or powder form, it is packaged under inert conditions to maintain integrity. Store in a cool, dry place away from moisture and light.

Properties

• CAS Number: 220210-56-0
• Complexity: 247
• IUPAC Name: (3-tert-butoxycarbonylphenyl)boronic acid
• InChI: InChI=1S/C11H15BO4/c1-11(2,3)16-10(13)8-5-4-6-9(7-8)12(14)15/h4-7,14-15H,1-3H3
• InChI Key: HVJDVHCPCSZDSR-UHFFFAOYSA-N
• Exact Mass: 222.1063391
• Molecular Formula: C11H15BO4
• Molecular Weight: 222.05
• SMILES: B(C1=CC(=CC=C1)C(=O)OC(C)(C)C)(O)O
• Topological: 66.8
• Monoisotopic Mass: 222.1063391
• Synonyms: {3-[(tert-butoxy)carbonyl]phenyl}boronic acid, (3-((Tert-butoxy)carbonyl)phenyl)boronic acid, 691-957-9, 220210-56-0, 3-tert-Butoxycarbonylphenylboronic acid, 3-(tert-butoxycarbonyl)phenylboronic acid, 3-(t-Butoxycarbonyl)phenylboronic acid, 3-t-Butoxycarbonylphenylboronic acid, (3-(tert-Butoxycarbonyl)phenyl)boronic acid, 3-(tert-Butoxycarbonyl)benzeneboronic acid, MFCD01630855, [3-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]boronic Acid, (3-tert-butoxycarbonylphenyl)boronic acid, [3-(tert-butoxycarbonyl)phenyl]boronic acid, tert-Butyl 3-boronobenzoate, 3-[t-Butoxycarbonyl]phenylboronic acid, 3-(tert-Butoxycarbonylphenyl)boronic acid, SCHEMBL521171, DTXSID40378351, HVJDVHCPCSZDSR-UHFFFAOYSA-N, BCP15386, CS-M2539, 3-t-butoxycarbonyl phenyl boronic acid, AKOS005146522, AB09321, 3-tert-Butoxycarbonylbenzeneboronic acid, NCGC00249537-01, 3-(tertbutoxycarbonyl)-phenylboronic acid, AS-15071, SY025720, 3-(tert-Butoxycarbonyl)-phenylboronic acid, 3-(tert-butoxycarbonyl)phenyl-boronic acid, 3-(tert-butoxycarbonylphenyl) boronic acid, 3-(tert-butoxycarbonyl)benzene boronic acid, DB-021748, B4726, EN300-755152, Z2044749184, 3-(tert-Butoxycarbonyl)phenylboronic Acid (contains varying amounts of Anhydride)

Application

(3-((Tert-butoxy)carbonyl)phenyl)boronic acid is widely used in Suzuki-Miyaura cross-coupling reactions to form biaryl compounds, a key step in pharmaceutical and agrochemical synthesis. Its Boc-protected phenyl group enhances stability during reactions, making it suitable for multi-step organic transformations. Researchers also employ it in the development of boron-containing polymers and advanced materials. This compound is particularly valuable in medicinal chemistry for constructing complex molecular architectures.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (85.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (85.7%)

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