Description

5,8-Dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-amine (CAS No. 219715-62-5) is a high-purity heterocyclic compound with the molecular formula C₇H₉N₅O₂. This specialized chemical features a triazolopyrimidine core substituted with dimethoxy and amine functional groups, making it a valuable intermediate for pharmaceutical and agrochemical research. With a molecular weight of 195.18 g/mol, it is supplied as a crystalline solid with ≥95% purity (HPLC). Ideal for medicinal chemistry applications, this compound is particularly useful in the development of kinase inhibitors and other biologically active molecules. Proper storage at 2-8°C in a tightly sealed container is recommended to ensure long-term stability.

Properties

• CAS Number: 219715-62-5
• Complexity: 205
• IUPAC Name: 5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-amine
• InChI: InChI=1S/C7H9N5O2/c1-13-4-3-9-7(14-2)12-5(4)10-6(8)11-12/h3H,1-2H3,(H2,8,11)
• InChI Key: DBJPBHJHAPAUQU-UHFFFAOYSA-N
• Exact Mass: 195.07562455
• Molecular Formula: C7H9N5O2
• Molecular Weight: 195.18
• SMILES: COC1=CN=C(N2C1=NC(=N2)N)OC
• Topological: 87.6
• Monoisotopic Mass: 195.07562455
• Synonyms: 5,8-Dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-amine, DTXSID70466114, 5,8-dimethoxy-(1,2,4)triazolo(1,5-c)pyrimidin-2-amine, DTXCID30416933, 875-177-8, 219715-62-5, 2-Amino-5,8-Dimethoxy-[1,2,4]Triazolo[1,5-C]Pyrimidine, [1,2,4]Triazolo[1,5-c]pyrimidin-2-amine, 5,8-dimethoxy-, 5,8-Dimethoxy(1,2,4)triazolo(1,5-C)pyrimidin-2-amine, 5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amine, 2-Amino-5,8-dimethoxy-(1,2,4)triazolo(1,5-C)pyrimidine, (1,2,4)Triazolo(1,5-C)pyrimidin-2-amine, 5,8-dimethoxy-, 2-Amino-5,8-dimethoxy(1,2,4)triazolo[1,5-c]pyrimidine, 2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine, MFCD17168561, SCHEMBL841314, BCP11311, AKOS015999945, CS-W006757, UNII-0129526470, AC-27550, AS-19932, DB-017447, D70654, EN300-3509381, Q27247522, 2-amino-5,8-dimethoxy[1,2,4]triazolo[l,5-c]pyrimidine, 2-amino-5,8-dimethoxy[1,2,4]-triazolo[1,5-c]pyrimidine, 5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine-2-ylamine, 5 pound not8-Dimethoxy-[1 pound not2 pound not4]triazolo[1 pound not5-c]pyrimidin-2-amine

Application

This compound serves as a key building block in medicinal chemistry for the synthesis of triazolopyrimidine-based drug candidates. Researchers utilize it in the development of potential kinase inhibitors targeting various disease pathways. The dimethoxy and amine substitutions make it particularly valuable for structure-activity relationship studies in anticancer and antimicrobial research. Its unique heterocyclic structure also finds applications in agrochemical research for novel pesticide development.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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