Description

2-Hydroxy-4-methyl-3-nitropyridine (CAS No. 21901-18-8) is a high-purity nitropyridine derivative with the molecular formula C₆H₆N₂O₃. This compound, also known by its IUPAC name 4-methyl-3-nitro-1H-pyridin-2-one, is a versatile heterocyclic building block widely used in pharmaceutical, agrochemical, and materials science research. Our product is synthesized under strict quality control to ensure superior purity and consistency, making it ideal for demanding applications. The compound features a reactive nitro group adjacent to a hydroxyl group on a pyridine ring, enabling diverse chemical transformations. Available in various quantities, it is supplied with comprehensive analytical data including ¹H NMR, HPLC, and mass spectrometry reports. Store in a cool, dry place protected from light to maintain stability.

Properties

• CAS Number: 21901-18-8
• Complexity: 272
• IUPAC Name: 4-methyl-3-nitro-1H-pyridin-2-one
• InChI: InChI=1S/C6H6N2O3/c1-4-2-3-7-6(9)5(4)8(10)11/h2-3H,1H3,(H,7,9)
• InChI Key: HZCWTTHQRMHIIE-UHFFFAOYSA-N
• Exact Mass: 154.03784206
• Molecular Formula: C6H6N2O3
• Molecular Weight: 154.12
• SMILES: CC1=C(C(=O)NC=C1)[N+](=O)[O-]
• Topological: 74.9
• Monoisotopic Mass: 154.03784206
• Synonyms: 2-Hydroxy-4-methyl-3-nitropyridine, DTXSID30323077, DTXCID30274196, 626-893-2, 21901-18-8, 4-methyl-3-nitropyridin-2-ol, 2-Hydroxy-3-nitro-4-picoline, 4-methyl-3-nitro-1H-pyridin-2-one, 4-Methyl-3-nitro-2-pyridone, 4-methyl-3-nitropyridin-2(1h)-one, 4-Methyl-3-nitro-2-pyridinone, 4-methyl-3-nitro-1,2-dihydropyridin-2-one, MFCD00010689, 2-Hydroxy-3-nitro-4-methylpyridine, 2-Hydroxy-4-methyl-3-nitropyridine, 98%, 2(1H)-Pyridinone, 4-methyl-3-nitro-, HZCWTTHQRMHIIE-UHFFFAOYSA-, NSC402986, SCHEMBL801243, 3-Nitro-4-methyl-2-pyridone, 4-Methyl-3-nitro-2-pyridinol, SCHEMBL4685683, 4-Methyl-3-nitro-2-pyridinol #, 4-methyl-3-nitrohydropyridin-2-one, 2-Hydroxy-3-nitro-4-picoline (2-Hydroxy-4-methyl-3-nitropyridine), MFCD00955770, SBB065276, AKOS015842218, AKOS024365000, AC-5431, CS-W008349, FH02158, NSC-402986, DS-10948, SY021194, DB-003967, H1170, ST50997645, EN300-77835, Z1416203198, 4-Methyl-3-nitro-2-pyridinol;2-Hydroxy-3-nitro-4-picoline

Application

2-Hydroxy-4-methyl-3-nitropyridine serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of antibacterial and antiviral agents. Researchers utilize this nitropyridine derivative in heterocyclic chemistry to construct complex molecular architectures for drug discovery programs. The compound’s reactive functional groups make it valuable for studying nitro-group reduction chemistry and ring modification reactions. It also finds application in materials science as a precursor for specialty chemicals and functional materials.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.